| Issue Date | Title | Author(s) | Type | Access |
| 1 | May-2017 | Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia | Ramalho, Ana Rita ; Toscano, Adriana ; Pereira, Paulo ; Girão, Henrique ; Gonçalves, Lino; Marques, Carla | article | openAccess |
| 2 | 5-Jan-2021 | Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease | Correia, Sónia C. ; Machado, Nuno J. ; Alves, Marco G; Oliveira, Pedro F. ; Moreira, Paula I. | article | openAccess |
| 3 | 29-Oct-2021 | Chenodeoxycholic Acid Has Non-Thermogenic, Mitodynamic Anti-Obesity Effects in an In Vitro CRISPR/Cas9 Model of Bile Acid Receptor TGR5 Knockdown | Teodoro, João S. ; Machado, Ivo F. ; Castela, Ana C. ; Amorim, João A. ; Jarak, Ivana ; Carvalho, Rui A. ; Palmeira, Carlos M. ; Rolo, Anabela P. | article | openAccess |
| 4 | 5-Oct-2021 | Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model | Carneiro, Tatiana J. ; Araújo, Rita ; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Batista de Carvalho, Ana L. M. ; Marques, Maria Paula M. ; Diniz, Carmen ; Gil, Ana M. | article | openAccess |
| 5 | 2-Jun-2021 | Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy | Brignole, Chiara; Bensa, Veronica; Fonseca, Nuno A. ; Del Zotto, Genny; Bruno, Silvia; Cruz, Ana F. ; Malaguti, Fabiana; Carlini, Barbara; Morandi, Fabio; Calarco, Enzo; Perri, Patrizia; Moura, Vera ; Emionite, Laura; Cilli, Michele; De Leonardis, Francesco; Tondo, Annalisa; Amoroso, Loredana; Conte, Massimo; Garaventa, Alberto; Sementa, Angela R.; Corrias, Maria V.; Ponzoni, Mirco; Moreira, João N. ; Pastorino, Fabio | article | openAccess |
| 6 | 15-Nov-2022 | Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects | Dewaeles, Edmone; Carvalho, Kévin; Fellah, Sandy; Sim, Jaewon; Boukrout, Nihad; Caillierez, Raphaelle; Ramakrishnan, Hariharan; Van der Hauwaert, Cynthia; Vijaya Shankara, Jhenkruthi; Martin, Nathalie; Massri, Noura; Launay, Agathe; Folger, Joseph K; Schutter, Clémentine de; Larrue, Romain; Loison, Ingrid; Goujon, Marine; Jung, Matthieu; Le Gras, Stéphanie; Gomez-Murcia, Victoria; Faivre, Emilie; Lemaire, Julie; Garat, Anne; Beauval, Nicolas; Maboudou, Patrice; Gnemmi, Viviane; Gibier, Jean-Baptiste; Buée, Luc; Abbadie, Corinne; Glowacki, Francois; Pottier, Nicolas; Perrais, Michael; Cunha, Rodrigo A. ; Annicotte, Jean-Sébastien; Laumet, Geoffroy; Blum, David; Cauffiez, Christelle | article | openAccess |
| 7 | Sep-2021 | Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases | Sousa-Lima, Inês; Kim, Hyun Jeong; Jones, John ; Kim, Young-Bum | article | openAccess |
| 8 | 24-Mar-2021 | Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling | Naia, Luana Carvalho ; Pinho, Catarina M.; Dentoni, Giacomo; Liu, Jianping; Leal, Nuno Santos; Ferreira, Duarte M. S.; Schreiner, Bernadette; Filadi, Riccardo; Fão, Lígia ; Connolly, Niamh M. C.; Forsell, Pontus; Nordvall, Gunnar; Shimozawa, Makoto; Greotti, Elisa; Basso, Emy; Theurey, Pierre; Gioran, Anna; Joselin, Alvin; Arsenian-Henriksson, Marie; Nilsson, Per; Rego, A. Cristina ; Ruas, Jorge L.; Park, David; Bano, Daniele; Pizzo, Paola; Prehn, Jochen H. M.; Ankarcrona, Maria | article | openAccess |
| 9 | 2020 | Anti-inflammatory potential of Portuguese thermal waters | Silva, A. ; Oliveira, A. S.; Vaz, C. V.; Correia, S.; Ferreira, R. ; Breitenfeld, L.; Martinez-de-Oliveira, J.; Palmeira-de-Oliveira, R.; Pereira, C. M. F. ; Palmeira-de-Oliveira, A.; Cruz, M. T. | article | openAccess |
| 10 | 2020 | PINK1/PARKIN signalling in neurodegeneration and neuroinflammation | Quinn, Peter M. J.; Moreira, Paula I. ; Ambrósio, António Francisco ; Alves, C. Henrique | article | openAccess |
| 11 | 9-Apr-2020 | Trehalose alleviates the phenotype of Machado-Joseph disease mouse models | Santana, Magda M. ; Paixão, Susana ; Cunha-Santos, Janete; Silva, Teresa Pereira ; Trevino-Garcia, Allyson; Gaspar, Laetitia da Silva ; Nóbrega, Clévio ; Nobre, Rui J. ; Cavadas, Cláudia ; Greif, Hagar; Almeida, Luís Pereira de | article | openAccess |
| 12 | 2018 | Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test | Matias, Mariana ; Silvestre, Samuel ; Falcão, Amílcar ; Alves, Gilberto | article | openAccess |
| 13 | 5-Nov-2020 | Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neurons | Silva, Diana F. ; Candeias, Emanuel ; Esteves, Ana Raquel Fernandes ; Magalhães, João Duarte ; Ferreira, I. Luísa ; Nunes-Costa, Daniela ; Rego, Ana Cristina ; Empadinhas, Nuno ; Cardoso, Sandra M. | article | openAccess |
| 14 | 28-Nov-2020 | An Anthocyanin-Rich Extract Obtained from Portuguese Blueberries Maintains Its Efficacy in Reducing Microglia-Driven Neuroinflammation after Simulated Digestion | Serra, Diana ; Henriques, Joana F. ; Serra, Teresa; Silva, Andreia Bento; Bronze, Maria Rosário; Dinis, Teresa C. P. ; Almeida, Leonor M. | article | openAccess |
| 15 | 14-Oct-2020 | The Coffee-Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation | Nehlig, Astrid; Cunha, Rodrigo A. | article | openAccess |
| 16 | 16-Apr-2020 | Glioblastoma hijacks microglial gene expression to support tumor growth | Maas, Sybren L. N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, Joana ; Sen, Pritha; Prabhakar, Shilpa; Hickman, Suzanne E.; Lai, Charles P.; Ting, David T.; Breakefield, Xandra O.; Broekman, Marike L. D.; El Khoury, Joseph | article | openAccess |
| 17 | 25-Jun-2021 | The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production | Simões, Inês C M; Amorim, Ricardo ; Teixeira, José; Karkucinska-Wieckowska, Agnieszka; Carvalho, Adriana ; Pereira, Susana P; Simões, Rui F. ; Szymanska, Sylwia; Dąbrowski, Michał; Janikiewicz, Justyna; Dobrzyń, Agnieszka; Oliveira, Paulo J; Potes, Yaiza; Wieckowski, Mariusz R. | article | openAccess |
| 18 | 14-Mar-2021 | Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein | Moreno, Maria João ; Martins, Patricia Alexandra Teles ; Bernardino, Eva F. ; Abel, Biebele; Ambudkar, Suresh V | article | openAccess |
| 19 | 13-Apr-2021 | A selective p53 activator and anticancer agent to improve colorectal cancer therapy | Ramos, Helena; Soares, Maria I. L. ; Silva, Joana; Raimundo, Liliana; Calheiros, Juliana; Gomes, Célia ; Reis, Flávio ; Monteiro, Filipe A.; Nunes, Cláudia; Reis, Salette ; Bosco, Bartolomeo; Piazza, Silvano; Domingues, Lucília; Chlapek, Petr; Vlcek, Petr; Fabian, Pavel; Rajado, Ana Teresa; Carvalho, A. T. P. ; Veselska, Renata; Inga, Alberto; Melo, Teresa M. V. D. Pinho e ; Saraiva, Lucília | article | openAccess |
| 20 | 22-Mar-2021 | Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming | Tawfik, Bassam; Martins, Joana S; Houy, Sébastien; Imig, Cordelia; Pinheiro, Paulo S. ; Wojcik, Sonja M; Brose, Nils; Cooper, Benjamin H; Sørensen, Jakob Balslev | article | openAccess |
| 21 | Jan-2020 | Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism | Almeida, Nuno; Carrara, Guia; Palmeira, Carlos M. ; Fernandes, Ana S.; Parsons, Maddy; Smith, Geoffrey L.; Saraiva, Nuno | article | openAccess |
| 22 | 20-Mar-2018 | MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner | Andriani, Francesca; Majorini, Maria Teresa; Mano, Miguel ; Landoni, Elena; Miceli, Rosalba; Facchinetti, Federica; Mensah, Mavis; Fontanella, Enrico; Dugo, Matteo; Giacca, Mauro; Pastorino, Ugo; Sozzi, Gabriella; Delia, Domenico; Roz, Luca; Lecis, Daniele | article | openAccess |
| 23 | 27-Mar-2018 | Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization | Sánchez-López, Elena ; Ettcheto, Miren; Egea, Maria Antonia; Espina, Marta; Cano, Amanda ; Calpena, Ana Cristina; Camins, Antoni; Carmona, Nuria; Silva, Amelia M.; Souto, Eliana B. ; García, Maria Luisa | article | openAccess |
| 24 | 2018 | MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo | Saraiva, Cláudia; Talhada, Daniela; Rai, Akhilesh ; Ferreira, Raquel; Ferreira, Lino ; Bernardino, Liliana ; Ruscher, Karsten | article | openAccess |
| 25 | 2018 | Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach? | Silva, Andreia F. ; Escada-Rebelo, Sara ; Amaral, Sandra ; Santos Tavares, Renata ; Schlatt, Stefan; Ramalho-Santos, João ; Mota, Paula C. | article | openAccess |
| 26 | 16-Jul-2018 | The exercise sex gap and the impact of the estrous cycle on exercise performance in mice | Aguiar, Aderbal S. ; Speck, Ana Elisa ; Amaral, Inês M. ; Canas, Paula M. ; Cunha, Rodrigo A. | article | openAccess |
| 27 | 12-Jun-2018 | Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington's Disease | Duarte, Ana I. ; Sjögren, Marie; Santos, Maria S. ; Oliveira, Catarina R. ; Moreira, Paula I. ; Björkqvist, Maria | article | openAccess |
| 28 | 2-Oct-2017 | Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenotype of tumor cells | Oliveira, Ana Isabel; Anjo, Sandra I. ; Vieira de Castro, Joana; Serra, Sofia C.; Salgado, António J. ; Manadas, Bruno ; Costa, Bruno M. | article | openAccess |
| 29 | 5-Dec-2017 | Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2 | Hachigian, Lea J.; Carmona, Vitor ; Fenster, Robert J.; Kulicke, Ruth; Heilbut, Adrian; Sittler, Annie; Almeida, Luís Pereira de ; Mesirov, Jill P.; Gao, Fan; Kolaczyk, Eric D.; Heiman, Myriam | article | openAccess |
| 30 | 23-Dec-2017 | Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs | Houy, Sébastien; Groffen, Alexander J; Ziomkiewicz, Iwona; Verhage, Matthijs; Pinheiro, Paulo S. ; Sørensen, Jakob Balslev | article | openAccess |
| 31 | 1-Jul-2017 | Id genes are essential for early heart formation | Cunningham, Thomas J.; Yu, Michael S.; McKeithan, Wesley L.; Spiering, Sean; Carrette, Florent; Huang, Chun-Teng; Bushway, Paul J.; Tierney, Matthew; Albini, Sonia; Giacca, Mauro; Mano, Miguel ; Puri, Pier Lorenzo; Sacco, Alessandra; Ruiz-Lozano, Pilar; Riou, Jean-Francois; Umbhauer, Muriel; Duester, Gregg; Mercola, Mark; Colas, Alexandre R. | article | openAccess |
| 32 | 2-Mar-2017 | Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity | Costa, Elisabete da; Melo, Tânia; Moreira, Ana S. P.; Bernardo, Carina; Helguero, Luisa; Ferreira, Isabel ; Cruz, Maria Teresa ; Rego, Andreia M.; Domingues, Pedro ; Calado, Ricardo ; Abreu, Maria H.; Domingues, Maria Rosário | article | openAccess |
| 33 | Jun-2017 | DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties | Soares, Joana; Espadinha, Margarida; Raimundo, Liliana; Ramos, Helena; Gomes, Ana Sara; Gomes, Sara; Loureiro, Joana B.; Inga, Alberto; Reis, Flávio ; Gomes, Célia ; Santos, Maria M. M.; Saraiva, Lucília | article | openAccess |
| 34 | 2017 | Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes | Gonçalves, Joana ; Violante, Inês R. ; Sereno, José ; Leitão, Ricardo A. ; Cai, Ying; Abrunhosa, Antero ; Silva, Ana Paula ; Silva, Alcino J.; Castelo-Branco, Miguel | article | openAccess |
| 35 | 11-May-2017 | Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation | Boto, Carlos ; Quartin, Emanuel ; Cai, Yijun; Martín-Lorenzo, Alberto; Cenador, María Begoña García; Pinto, Sandra ; Gupta, Rajeev; Enver, Tariq; Sánchez-García, Isidro; Hong, Dengli; Neves, Ricardo Pires das ; Ferreira, Lino | article | openAccess |
| 36 | 19-Jan-2017 | Glucocorticoid receptor signalling activates YAP in breast cancer | Sorrentino, Giovanni; Ruggeri, Naomi; Zannini, Alessandro; Ingallina, Eleonora; Bertolio, Rebecca; Marotta, Carolina; Neri, Carmelo; Cappuzzello, Elisa; Forcato, Mattia; Rosato, Antonio; Mano, Miguel ; Bicciato, Silvio; Del Sal, Giannino | article | openAccess |
| 37 | Oct-2017 | Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus | Robledinos-Antón, Natalia; Rojo, Ana I; Ferreiro, Elisabete ; Núñez, Ángel; Krause, Karl-Heinz; Jaquet, Vincent; Cuadrado, Antonio | article | openAccess |
| 38 | 25-Aug-2017 | The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo | Morató, Xavier; Luján, Rafael; López-Cano, Marc; Gandía, Jorge; Stagljar, Igor; Watanabe, Masahiko; Cunha, Rodrigo A. ; Fernández-Dueñas, Víctor; Ciruela, Francisco | article | openAccess |
| 39 | 24-Oct-2017 | Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease | Sjögren, Marie; Duarte, Ana I. ; McCourt, Andrew C.; Shcherbina, Liliya; Wierup, Nils; Björkqvist, Maria | article | openAccess |
| 40 | 8-Aug-2017 | Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software | Perestrelo, Tânia ; Chen, Weitong; Correia, Marcelo ; Le, Christopher; Pereira, Sandro ; Rodrigues, Ana S. ; Sousa, Maria I. ; Ramalho-Santos, João ; Wirtz, Denis | article | openAccess |
| 41 | 11-Jul-2017 | Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate | Freire, Ana G.; Waghray, Avinash; Soares-da-Silva, Francisca ; Resende, Tatiana P.; Lee, Dung-Fang; Pereira, Carlos Filipe ; Nascimento, Diana S.; Lemischka, Ihor R.; Pinto-do-Ó, Perpétua | article | openAccess |
| 42 | 21-Oct-2016 | Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells | Ferreira-Teixeira, Margarida ; Paiva-Oliveira, Daniela ; Parada, Belmiro ; Alves, Vera ; Sousa, Vítor ; Chijioke, Obinna; Münz, Christian; Reis, Flávio ; Rodrigues-Santos, Paulo ; Gomes, Célia | article | openAccess |
| 43 | 10-Jun-2016 | Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity | Moidunny, Shamsudheen; Matos, Marco ; Wesseling, Evelyn; Banerjee, Santanu; Volsky, David J.; Cunha, Rodrigo A.; Agostinho, Paula ; Boddeke, Hendrikus W.; Roy, Sabita | article | openAccess |
| 44 | 17-Jun-2016 | Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors | Silva, Sílvia Viana da ; Haberl, Matthias Georg; Zhang, Pei; Bethge, Philipp; Lemos, Cristina ; Gonçalves, Nélio ; Gorlewicz, Adam; Malezieux, Meryl; Gonçalves, Francisco Q. ; Grosjean, Noëlle; Blanchet, Christophe; Frick, Andreas; Nägerl, U Valentin; Cunha, Rodrigo A. ; Mulle, Christophe | article | openAccess |
| 45 | 26-Jan-2016 | Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule | Soares, Joana; Raimundo, Liliana; Pereira, Nuno A. L.; Monteiro, Ângelo; Gomes, Sara; Bessa, Cláudia; Pereira, Clara; Queiroz, Glória; Bisio, Alessandra; Fernandes, João ; Gomes, Célia ; Reis, Flávio ; Gonçalves, Jorge; Inga, Alberto; Santos, Maria M. M.; Saraiva, Lucília | article | openAccess |
| 46 | 27-Sep-2016 | Blunted dynamics of adenosine A2A receptors is associated with increased susceptibility to Candida albicans infection in the elderly | Rodrigues, Lisa ; Miranda, Isabel M.; Andrade, Geanne M. ; Mota, Marta ; Cortes, Luísa ; Rodrigues, Acácio G.; Cunha, Rodrigo A. ; Gonçalves, Teresa | article | openAccess |
| 47 | 2016 | Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model | Gregório, Ana C. ; Fonseca, Nuno A. ; Moura, Vera ; Lacerda, Manuela ; Figueiredo, Paulo; Simões, Sérgio ; Dias, Sérgio; Moreira, João Nuno | article | openAccess |
| 48 | 21-Jul-2015 | Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis | Schneeberger, Marc; Gómez-Valadés, Alicia G.; Altirriba, Jordi; Sebastián, David; Ramírez, Sara; Garcia, Ainhoa; Esteban, Yaiza; Drougard, Anne; Ferrés-Coy, Albert; Bortolozzi, Analía; Garcia-Roves, Pablo M.; Jones, John G. ; Manadas, Bruno ; Zorzano, Antonio; Gomis, Ramon; Claret, Marc | article | openAccess |
| 49 | 12-Feb-2015 | Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons | Curcio, M.; Salazar, I. L. ; Inácio, A. R.; Duarte, E. P. ; Canzoniero, L. M. T.; Duarte, C. B. | article | openAccess |
| 50 | 8-Dec-2015 | Intravenous Single-Dose Toxicity of Redaporfin-Based Photodynamic Therapy in Rodents | Rocha, Luis B.; Schaberle, Fábio António ; Dąbrowski, Janusz M. ; Simões, Sérgio; Arnaut, Luís G. | article | openAccess |
