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Mano, Miguel
Mano, Miguel
Mano, Miguel
Mano, M.
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Miguel Mano graduated in Biochemistry from the University of Coimbra, Portugal, and obtained a PhD degree in Biochemistry from the University of Coimbra, Portugal, in 2006. After the PhD, M. Mano worked as a Post-Doctoral fellow (2006-2008) at the Molecular Medicine laboratory at the International Centre for Genetic Engineering and Biotechnology (ICGEB, Trieste, Italy). Starting in 2008, M. Mano has taken the position of Scientific Manager of the High-Throughput Screening Facility at the ICGEB (Trieste, Italy), the first established in an academic research laboratory in Italy. In 2011, M. Mano became Staff Research Scientist at the ICGEB.
In 2014, Miguel Mano established an independent laboratory at the Centre for Neuroscience and Cell Biology (CNC, Coimbra, Portugal), under the “FCT Investigator Programme” from the Portuguese Science Foundation (FCT, Portugal) and in 2018 M. Mano became Principal Investigator at CNC. Since 2020, M. Mano is Assistant Professor at the Department of Life Sciences at the University of Coimbra.

The ‘Functional Genomics and RNA-based Therapeutics’ laboratory, headed by Miguel Mano, hosts a state-of-the-art high-throughput screening platform equipped with adequate instrumentation, libraries and expertise to perform genome-wide siRNA and microRNA and CRISPR screenings in human and mouse cellular models.
The research of the ‘Functional Genomics and RNA-based Therapeutics’ laboratory is focused on two main areas: i) the identification and molecular characterization of novel cellular factors relevant to cardiac repair and regeneration, and the translation of this knowledge into effective RNA-based therapeutic strategies, and ii) the development of high-throughput and high-content screening technologies genome-wide siRNA, CRISPR and microRNA libraries.

M. Mano has published 50 papers in international peer-reviewed journals, including papers in high impact factor journals (Nature, Nature Cell Biology, PNAS, Nature Communications, Nature Microbiology, Cancer Cell), which received over 2600 citations; h-index 22. M. Mano is also a co-inventor of 2 patents related to the clinical development of miRNAs for cardiovascular diseases.

M. Mano has received PhD and Post-Doctoral fellowships from the Portuguese Science Foundation (FCT). In 2011 he has been awarded the prestigious Excellence in Research Award from the American Society for Gene and Cell Therapy (ASGCT).

M. Mano has obtained funding, as Principal Investigator, from different funding agencies (total funding exceeding 650,000€ since July 2014).
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Results 1-22 of 22 (Search time: 0.029 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Apr-2017Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodiaSunkavalli, Ushasree; Aguilar, Carmen; Silva, Ricardo Jorge ; Sharan, Malvika; Cruz, Ana Rita ; Tawk, Caroline; Maudet, Claire; Mano, Miguel ; Eulálio, Ana articleopenAccess
2Jun-2016Cardiac ischemia-reperfusion injury : in vitro models and regulation by microRNAsVideira, Raquel FiguinhamasterThesisembargoedAccess
330-Mar-2010Cell-Penetrating Peptides - Mechanisms of Cellular Uptake and Generation of Delivery SystemsTrabulo, Sara ; Cardoso, Ana Luísa ; Mano, Miguel ; Lima, Maria C. Pedroso de reviewopenAccess
430-Mar-2010Cell-Penetrating Peptides-Mechanisms of Cellular Uptake and Generation of Delivery SystemsTrabulo, Sara ; Cardoso, Ana Luísa ; Mano, Miguel ; Lima, Maria C. Pedroso de articleopenAccess
525-Feb-2019Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradationAli, Hashim; Mano, Miguel ; Braga, Luca; Naseem, Asma; Marini, Bruna; Vu, Diem My; Collesi, Chiara; Meroni, Germana; Lusic, Marina; Giacca, MauroarticleopenAccess
619-Jun-2020Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcriptionSorino, Cristina; Catena, Valeria; Bruno, Tiziana; De Nicola, Francesca; Scalera, Stefano; Bossi, Gianluca; Fabretti, Francesca; Mano, Miguel ; De Smaele, Enrico; Fanciulli, Maurizio; Iezzi, SimonaarticleopenAccess
72021Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease CardiomyopathyNunes, João Paulo Silva; Andrieux, Pauline; Brochet, Pauline; Almeida, Rafael Ribeiro; Kitano, Eduardo; Honda, André Kenji; Iwai, Leo Kei; Andrade-Silva, Débora; Goudenège, David; Alcântara Silva, Karla Deysiree; Vieira, Raquel de Souza; Levy, Débora; Bydlowski, Sergio Paulo; Gallardo, Frédéric; Torres, Magali; Bocchi, Edimar Alcides; Mano, Miguel ; Santos, Ronaldo Honorato Barros; Bacal, Fernando; Pomerantzeff, Pablo; Laurindo, Francisco Rafael Martins; Teixeira, Priscila Camillo; Nakaya, Helder I; Kalil, Jorge; Procaccio, Vincent; Chevillard, Christophe; Cunha-Neto, EdecioarticleopenAccess
85-Sep-2019Dissection of the Role of MicroRNAs in Cardiac FibrosisRodrigues, Flávia Sofia MaiamasterThesisembargoedAccess
92004Electrochemical sensing of the behaviour of oligonucleotide lipoplexes at charged interfacesPiedade, J. A. P. ; Mano, M. ; Lima, M. C. Pedroso de ; Oretskaya, T. S. ; Oliveira-Brett, A. M. articleopenAccess
1019-Jan-2017Glucocorticoid receptor signalling activates YAP in breast cancerSorrentino, Giovanni; Ruggeri, Naomi; Zannini, Alessandro; Ingallina, Eleonora; Bertolio, Rebecca; Marotta, Carolina; Neri, Carmelo; Cappuzzello, Elisa; Forcato, Mattia; Rosato, Antonio; Mano, Miguel ; Bicciato, Silvio; Del Sal, GianninoarticleopenAccess
118-Jul-2019High-content screen in human pluripotent cells identifies miRNA-regulated pathways controlling pluripotency and differentiationde Souza Lima, Ildercílio Mota; Schiavinato, Josiane Lilian Dos Santos; Paulino Leite, Sarah Blima; Sastre, Danuta; Bezerra, Hudson Lenormando de Oliveira; Sangiorgi, Bruno; Corveloni, Amanda Cristina; Thomé, Carolina Hassibe; Faça, Vitor Marcel; Covas, Dimas Tadeu; Zago, Marco Antônio; Giacca, Mauro; Mano, Miguel ; Panepucci, Rodrigo AlexandrearticleopenAccess
121-Jul-2017Id genes are essential for early heart formationCunningham, Thomas J.; Yu, Michael S.; McKeithan, Wesley L.; Spiering, Sean; Carrette, Florent; Huang, Chun-Teng; Bushway, Paul J.; Tierney, Matthew; Albini, Sonia; Giacca, Mauro; Mano, Miguel ; Puri, Pier Lorenzo; Sacco, Alessandra; Ruiz-Lozano, Pilar; Riou, Jean-Francois; Umbhauer, Muriel; Duester, Gregg; Mercola, Mark; Colas, Alexandre R.articleopenAccess
132007Interaction of S413-PV cell penetrating peptide with model membranes: relevance to peptide translocation across biological membranesMano, Miguel ; Henriques, Ana ; Paiva, Artur ; Prieto, Manuel ; Gavilanes, Francisco ; Simões, Sérgio ; Lima, Maria C. Pedroso De articleopenAccess
1422-Nov-2022Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent featureLopes, Ines Rodrigues; Alcantara, Laura Maria; Silva, Ricardo Jorge ; Josse, Jerome; Vega, Elena Pedrero; Cabrerizo, Ana Marina; Bonhomme, Melanie; Lopez, Daniel; Laurent, Frederic; Vandenesch, Francois; Mano, Miguel ; Eulálio, Ana articleopenAccess
1520-Mar-2018MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent mannerAndriani, Francesca; Majorini, Maria Teresa; Mano, Miguel ; Landoni, Elena; Miceli, Rosalba; Facchinetti, Federica; Mensah, Mavis; Fontanella, Enrico; Dugo, Matteo; Giacca, Mauro; Pastorino, Ugo; Sozzi, Gabriella; Delia, Domenico; Roz, Luca; Lecis, DanielearticleopenAccess
1611-Jan-2023MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancerDinami, Roberto; Pompili, Luca; Petti, Eleonora; Porru, Manuela; D'Angelo, Carmen; Di Vito, Serena; Rizzo, Angela; Campani, Virginia; De Rosa, Giuseppe; Bruna, Alejandra; Serra, Violeta; Mano, Miguel ; Giacca, Mauro; Leonetti, Carlo; Ciliberto, Gennaro; Tarsounas, Madalena; Stoppacciaro, Antonella; Schoeftner, Stefan; Biroccio, AnnamariaarticleopenAccess
171-Sep-2005On the mechanisms of the internalization of S4(13)-PV cell-penetrating peptideMano, Miguel ; Teodósio, Cristina ; Paiva, Artur ; Simões, Sérgio ; Lima, Maria C. Pedroso de articleopenAccess
1810-Feb-2006Péptidos permeantes como sistemas promissores para transporte de ácidos nucleicos : mecanismos de internalização celular e actividade biológica do péptido S413-PVMano, Miguel Luís Cunha doctoralThesisembargoedAccess
192021Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cellsAguilar, Carmen; Costa, Susana ; Maudet, Claire; Vivek-Ananth, R P; Zaldívar-López, Sara; Garrido, Juan J; Samal, Areejit; Mano, Miguel ; Eulálio, Ana articleopenAccess
202008S4 13 - PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNATrabulo, Sara ; Mano, Miguel ; Faneca, Henrique ; Cardoso, Ana Luísa ; Duarte, Sónia ; Henriques, Ana ; Paiva, Artur ; Gomes, Paula ; Simões, Sérgio ; Lima, Maria C. Pedroso de articleopenAccess
2122-Mar-2019Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolismBertolio, Rebecca; Napoletano, Francesco; Mano, Miguel ; Maurer-Stroh, Sebastian; Fantuz, Marco; Zannini, Alessandro; Bicciato, Silvio; Sorrentino, Giovanni; Del Sal, GianninoarticleopenAccess
222004Voltammetric behaviour of oligonucleotide lipoplexes adsorbed onto glassy carbon electrodesPiedade, J. A. P. ; Mano, M. ; Lima, M. C. Pedroso de ; Oretskaya, T. S. ; Oliveira-Brett, A. M. articleopenAccess