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Credit Name
Empadinhas, Nuno
 
Name
Empadinhas, Nuno
 
Variants
Empadinhas, Nuno
 
 
Email
nuno.empadinhas@uc.pt
 
Other emails
 
 
Ciência ID
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Nuno Empadinhas graduated in Biology and received a PhD in Biochemistry with specialty in Microbiology from the University of Coimbra (UC). He is Principal Investigator and Group Leader at the Center for Neuroscience and Cell Biology (CNC) at the UC. His research in Microbial Physiology has focused on deciphering molecular mechanisms of microbial adaptation to stress. He has studied microbes from extreme environments, mycobacterial pathogens and more recently the microbiota from the also extreme gut ecosystem. He has co-organized field research expeditions to isolate microbes from hotsprings and probed their biotechnological potential as producers of stabilizers of cells or proteins. In this context, he has elucidated biosynthetic pathways for compatible solutes in hyperthermophilic archaea, in thermophilic bacteria, and in desiccation/radiation resistant microbes. He has elucidated biosynthetic pathways for polymethylated lipid-transfer polysaccharides (PMPS) in Mycobacterium tuberculosis and in nontuberculous mycobacteria (NTM), many of which exceptionally resistant to stress agents including antibiotics, partly owing to an exceptional lipid-rich cell envelope and indirectly to PMPS. He secured funding to investigate the gut microbiome of Parkinson's patients and the biosynthesis of microbial neurotoxins, and also the diabetic skin and ulcers' microbiome, which led to an extensive culture collection of strains from these ecosystems. In his career as molecular microbiologist, he identified gene functions and enzyme activities that were the founding members of 14 new families at the IUBMB Nomenclature. He supervised or co-supervised 10 PhD and 12 Master students and 4 post-doctoral fellows, was invited speaker at >30 conferences, co-inventor in 2 international patents, published 3 book chapters and 59 papers, many of which in Top 10% Journals such as J Biol Chem, J Bacteriol, Mol Microbiol, Nat Prod Rep, mBio and PNAS. In 2021, he was awarded with the Mizutani Grant, the only time attributed to a scientist in Portugal since its foundation in 1993. In the last 10 years, he has coordinated and co-coordinated 10 projects with global funding >1.5 M euro by Fundação para a Ciência e a Tecnologia, Santa Casa da Misericórdia de Lisboa, Infarmed, Mizutani Foundation for Glycoscience (Japan), and participated in 15 other projects including 3 funded by the European Commission.
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Publications
(All)

Results 1-39 of 39 (Search time: 0.048 seconds).

Issue DateTitleAuthor(s)TypeAccess
12012Análise funcional de maltocinases e trealose sintases/maltocinases bifuncionaisLamaroso, Andreia Filipa Nisa Mendes masterThesisopenAccess
2Sep-2016Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em streptacidiphilus jiangxiensis sob diferentes condições de stressMartins, Cristina Isabel da SilvamasterThesisopenAccess
32013Biosynthesis of rare methylglucose lipopolysaccharides in rapidly-growing mycobacteria : characterization of a key hydrolaseCosta, Maria Mafalda Santos masterThesisopenAccess
419-Nov-2021Biosynthesis of serotonin in bacteria: an exploratory studyGonçalves, Sara Miguel masterThesisopenAccess
5Sep-2016Colesterol oxidase, hormonas sexuais e suscetibilidade à tuberculose : um estudo exploratórioMonteiro, Ana Catarina SilvamasterThesisopenAccess
6Sep-2006Diversity and biosynthesis of compatible solutes in hyper/thermophilesEmpadinhas, Nuno ; Costa, Milton S. da articleopenAccess
72020Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immune SystemOriá, Reinaldo B; Empadinhas, Nuno ; Malva, João O. articleopenAccess
827-Sep-2019Esterilização supercrítica de aerogéis compostos por polímeros naturais para aplicações biomédicasBento, Cristiana Sofia AmaralmasterThesisembargoedAccess
926-Nov-2021Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondriaEsteves, A. Raquel ; Munoz-Pinto, Mário F.; Nunes-Costa, Daniela; Candeias, Emanuel ; Silva, Diana F. ; Magalhães, João D.; Pereira-Santos, A. Raquel ; Ferreira, I. Luisa; Alarico, Susana ; Tiago, Igor ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess
10Jan-2023Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondriaEsteves, A. Raquel ; Munoz-Pinto, Mário F; Nunes-Costa, Daniela ; Candeias, Emanuel ; Silva, Diana F. F. ; Magalhães, João Duarte ; Santos, A. Raquel Pereira ; Ferreira, Ildete L. ; Alarico, Susana ; Tiago, Igor ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess
1126-Jul-2021Identificação de proteínas de micobactérias não tuberculosas envolvidas na agregação celular e formação de biofilmeFonseca, Ana Rita MarquesmasterThesisembargoedAccess
1212-Mar-2021Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiotaMouritzen, Michelle V.; Petkovic, Marija ; Qvist, Katrine; Poulsen, Steen S.; Alarico, Susana ; Leal, Ermelindo C. ; Dalgaard, Louise T.; Empadinhas, Nuno ; Carvalho, Eugenia ; Jenssen, HåvardarticleopenAccess
132007Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1Alarico, Susana ; Empadinhas, Nuno ; Mingote, Ana ; Simões, Catarina ; Santos, Maria ; Costa, Milton da articleopenAccess
142020Microbial BMAA and the Pathway for Parkinson's Disease NeurodegenerationNunes-Costa, Daniela ; Magalhães, João Duarte ; G-Fernandes, Maria ; Cardoso, Sandra Morais ; Empadinhas, Nuno articleopenAccess
155-Nov-2020Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neuronsSilva, Diana F. ; Candeias, Emanuel ; Esteves, Ana Raquel Fernandes ; Magalhães, João Duarte ; Ferreira, I. Luísa ; Nunes-Costa, Daniela ; Rego, Ana Cristina ; Empadinhas, Nuno ; Cardoso, Sandra M. articleopenAccess
162017Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment StrategiesPereira, Sónia G. ; Moura, João ; Carvalho, Eugenia ; Empadinhas, Nuno articleopenAccess
172015Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteriaCosta, Daniela Cristina Nunes masterThesisopenAccess
1813-Jan-2016Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesisTiago, Ana Branco Maranha doctoralThesisopenAccess
1914-May-2019Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase ActivityManso, José A.; Nunes-Costa, Daniela ; Macedo-Ribeiro, Sandra ; Empadinhas, Nuno ; Pereira, Pedro José BarbosaarticleopenAccess
202010A multifactorial approach to the biological role of the mycobacterial maltokinaseTiago, Ana Branco Maranha masterThesisopenAccess
2122-Jul-2019Mycobacterial methylmannose polysaccharides’ biosynthesisCosta, Maria Mafalda Santos doctoralThesisembargoedAccess
2224-Oct-2014Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerateAlarico, Susana ; Costa, Maria Mafalda Santos ; Sousa, Marta S. ; Maranha, Ana ; Lourenço, Eva C.; Faria, Tiago Q. ; Ventura, M. Rita; Empadinhas, Nuno articleopenAccess
232008Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesisPereira, Pedro José Barbosa; Empadinhas, Nuno ; Albuquerque, Luciana ; Sá-Moura, Bebiana ; Costa, Milton S. da ; Macedo-Ribeiro, Sandra articleopenAccess
242011Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesisMendes, Vítor ; Maranha, Ana ; Alarico, Susana ; Costa, Milton S. da ; Empadinhas, Nuno articleopenAccess
2516-Apr-2024Neuronal control of microglia through the mitochondriaPereira-Santos, A. R. ; Candeias, Emanuel ; Magalhães, J. D. ; Empadinhas, Nuno ; Esteves, A. Raquel ; Cardoso, Sandra Morais articleopenAccess
269-Dec-2011New insights into the biosynthesis of the Mycobacterial Methylglucose LipopolysaccharideMendes, Vítor Gonçalo Silva e Costa doctoralThesisopenAccess
271-Sep-2015Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharidesMaranha, Ana ; Moynihan, Patrick J.; Miranda, Vanessa; Correia Lourenço, Eva; Nunes-Costa, Daniela ; Fraga, Joana ; José Barbosa Pereira, Pedro; Macedo-Ribeiro, Sandra ; Ventura, M. Rita; Clarke, Anthony J.; Empadinhas, Nuno articleopenAccess
282007Organic solutes in Rubrobacter xylanophilus : the first example of di- myo -inositol-phosphate in a thermophileEmpadinhas, Nuno ; Mendes, Vítor ; Simões, Catarina ; Santos, Maria ; Mingote, Ana ; Lamosa, Pedro ; Santos, Helena ; Costa, Milton articleopenAccess
293-Feb-2005Pathways for the synthesis of mannosylglycerate in prokaryotes: genes, enzymes and evolutionary implicationsEmpadinhas, Nuno Miguel da Silva doctoralThesisembargoedAccess
3030-Mar-2009Relevance of mannosyglycerate and trehalose accumulation in the osmoadaptation of Thermus thermophilusAlarico, Susana Isabel Elias doctoralThesisembargoedAccess
3127-Jan-2023Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharidesMaranha, Ana ; Costa, Mafalda ; Ripoll-Rozada, Jorge; Manso, José A.; Miranda, Vanessa; Mendes, Vera M. ; Manadas, Bruno ; Macedo-Ribeiro, Sandra ; Ventura, M. Rita; Pereira, Pedro José Barbosa; Empadinhas, Nuno articleopenAccess
3226-Jan-2015Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathwayFraga, Joana ; Maranha, Ana ; Mendes, Vítor ; Pereira, Pedro José Barbosa; Empadinhas, Nuno ; Macedo-Ribeiro, Sandra articleopenAccess
3330-Nov-2015Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanismMendes, Vítor ; Blaszczyk, Michal; Maranha, Ana ; Empadinhas, Nuno ; Blundell, Tom L.articleopenAccess
3419-Mar-2019Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environmentPereira, Sónia Gonçalves ; Alarico, Susana ; Tiago, Igor ; Reis, Diogo ; Nunes-Costa, Daniela ; Cardoso, Olga ; Maranha, Ana ; Empadinhas, Nuno articleopenAccess
352018The Microbiome-Mitochondria Dance in Prodromal Parkinson's DiseaseCardoso, Sandra M. ; Empadinhas, Nuno articleopenAccess
362021The neuromicrobiology of Parkinson's disease: A unifying theoryMunoz-Pinto, Mario F.; Empadinhas, Nuno Miguel da Silva ; Cardoso, Sandra M. articleopenAccess
3722-Feb-2023The Role of Bacteria-Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson's DiseaseMagalhães, João Duarte ; Esteves, A. Raquel ; Candeias, Emanuel ; Silva, Diana F. F. ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess
381-Jul-2019The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen starvationCereija, Tatiana Barros; Alarico, Susana ; Lourenço, Eva C.; Manso, José António; Ventura, M. Rita; Empadinhas, Nuno ; Macedo-Ribeiro, Sandra ; Pereira, Pedro José BarbosaarticleopenAccess
392008To be or not to be a compatible solute: Bioversatility of mannosylglycerate and glucosylglycerateEmpadinhas, Nuno ; Costa, Milton S. da articleopenAccess