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Empadinhas, Nuno
Empadinhas, Nuno
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Nuno Empadinhas graduated in Biology and received a PhD in Biochemistry with specialty in Microbiology from the University of Coimbra (UC). He is Principal Investigator and Group Leader at the Center for Neuroscience and Cell Biology (CNC) at the UC. His research in Microbial Physiology has focused on deciphering molecular mechanisms of microbial adaptation to stress. He has studied microbes from extreme environments, mycobacterial pathogens and more recently the microbiota from the also extreme gut ecosystem. He has co-organized field research expeditions to isolate microbes from hotsprings and probed their biotechnological potential as producers of stabilizers of cells or proteins. In this context, he has elucidated biosynthetic pathways for compatible solutes in hyperthermophilic archaea, in thermophilic bacteria, and in desiccation/radiation resistant microbes. He has elucidated biosynthetic pathways for polymethylated lipid-transfer polysaccharides (PMPS) in Mycobacterium tuberculosis and in nontuberculous mycobacteria (NTM), many of which exceptionally resistant to stress agents including antibiotics, partly owing to an exceptional lipid-rich cell envelope and indirectly to PMPS. He secured funding to investigate the gut microbiome of Parkinson's patients and the biosynthesis of microbial neurotoxins, and also the diabetic skin and ulcers' microbiome, which led to an extensive culture collection of strains from these ecosystems. In his career as molecular microbiologist, he identified gene functions and enzyme activities that were the founding members of 14 new families at the IUBMB Nomenclature. He supervised or co-supervised 10 PhD and 12 Master students and 4 post-doctoral fellows, was invited speaker at >30 conferences, co-inventor in 2 international patents, published 3 book chapters and 59 papers, many of which in Top 10% Journals such as J Biol Chem, J Bacteriol, Mol Microbiol, Nat Prod Rep, mBio and PNAS. In 2021, he was awarded with the Mizutani Grant, the only time attributed to a scientist in Portugal since its foundation in 1993. In the last 10 years, he has coordinated and co-coordinated 10 projects with global funding >1.5 M euro by Fundação para a Ciência e a Tecnologia, Santa Casa da Misericórdia de Lisboa, Infarmed, Mizutani Foundation for Glycoscience (Japan), and participated in 15 other projects including 3 funded by the European Commission.
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UC Researcher


Results 1-22 of 22 (Search time: 0.105 seconds).

Issue DateTitleAuthor(s)TypeAccess
12012Análise funcional de maltocinases e trealose sintases/maltocinases bifuncionaisLamaroso, Andreia Filipa Nisa Mendes masterThesisopenAccess
2Sep-2016Avaliação do potencial antimicrobiano e síntese de glucosilglicerato em streptacidiphilus jiangxiensis sob diferentes condições de stressMartins, Cristina Isabel da SilvamasterThesisopenAccess
32013Biosynthesis of rare methylglucose lipopolysaccharides in rapidly-growing mycobacteria : characterization of a key hydrolaseCosta, Maria Mafalda Santos masterThesisopenAccess
419-Nov-2021Biosynthesis of serotonin in bacteria: an exploratory studyGonçalves, Sara Miguel masterThesisopenAccess
5Sep-2016Colesterol oxidase, hormonas sexuais e suscetibilidade à tuberculose : um estudo exploratórioMonteiro, Ana Catarina SilvamasterThesisopenAccess
6Sep-2006Diversity and biosynthesis of compatible solutes in hyper/thermophilesEmpadinhas, Nuno ; Costa, Milton S. da articleopenAccess
72020Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immune SystemOriá, Reinaldo B; Empadinhas, Nuno ; Malva, João O. articleopenAccess
82022Enzyme Promiscuity in Serotonin Biosynthesis, From Bacteria to Plants and HumansGonçalves, Sara ; Nunes-Costa, Daniela; Cardoso, Sandra Morais ; Empadinhas, Nuno ; Marugg, John David articleopenAccess
927-Sep-2019Esterilização supercrítica de aerogéis compostos por polímeros naturais para aplicações biomédicasBento, Cristiana Sofia AmaralmasterThesisembargoedAccess
1026-Nov-2021Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondriaEsteves, A. Raquel ; Munoz-Pinto, Mário F.; Nunes-Costa, Daniela; Candeias, Emanuel ; Silva, Diana F. ; Magalhães, João D.; Pereira-Santos, A. Raquel ; Ferreira, I. Luisa; Alarico, Susana ; Tiago, Igor ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess
1126-Jul-2021Identificação de proteínas de micobactérias não tuberculosas envolvidas na agregação celular e formação de biofilmeFonseca, Ana Rita MarquesmasterThesisembargoedAccess
122007Mannosylglycerate is essential for osmotic adjustment in Thermus thermophilus strains HB27 and RQ-1Alarico, Susana ; Empadinhas, Nuno ; Mingote, Ana ; Simões, Catarina ; Santos, Maria ; Costa, Milton da articleopenAccess
132015Molecular and biochemical characterization of a rare glucokinase with a cryptic function in environmental mycobacteriaCosta, Daniela Cristina Nunes masterThesisopenAccess
1413-Jan-2016Molecular and biochemical studies of a mycobacterial maltokinase and a unique octanoyltransferase: Towards reconstruction of the pathway for methylglucose lipopolysaccharides biosynthesisTiago, Ana Branco Maranha doctoralThesisopenAccess
152010A multifactorial approach to the biological role of the mycobacterial maltokinaseTiago, Ana Branco Maranha masterThesisopenAccess
1622-Jul-2019Mycobacterial methylmannose polysaccharides’ biosynthesisCosta, Maria Mafalda Santos doctoralThesisembargoedAccess
179-Dec-2011New insights into the biosynthesis of the Mycobacterial Methylglucose LipopolysaccharideMendes, Vítor Gonçalo Silva e Costa doctoralThesisopenAccess
182007Organic solutes in Rubrobacter xylanophilus : the first example of di- myo -inositol-phosphate in a thermophileEmpadinhas, Nuno ; Mendes, Vítor ; Simões, Catarina ; Santos, Maria ; Mingote, Ana ; Lamosa, Pedro ; Santos, Helena ; Costa, Milton articleopenAccess
193-Feb-2005Pathways for the synthesis of mannosylglycerate in prokaryotes: genes, enzymes and evolutionary implicationsEmpadinhas, Nuno Miguel da Silva doctoralThesisembargoedAccess
2030-Mar-2009Relevance of mannosyglycerate and trehalose accumulation in the osmoadaptation of Thermus thermophilusAlarico, Susana Isabel Elias doctoralThesisembargoedAccess
212021The neuromicrobiology of Parkinson's disease: A unifying theoryMunoz-Pinto, Mario F.; Empadinhas, Nuno Miguel da Silva ; Cardoso, Sandra M. articleopenAccess
222008To be or not to be a compatible solute: Bioversatility of mannosylglycerate and glucosylglycerateEmpadinhas, Nuno ; Costa, Milton S. da articleopenAccess