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Credit Name
Eugenia Carvalho
Carvalho, Eugenia
Dr. Carvalho, PI at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra (UC), studies underlying cellular and molecular mechanisms that are in the origin of diabetes and complications. She has discovered that low insulin receptor substrate-1 protein levels in fat are predictors of pre-diabetes. She investigates insulin resistance and metabolic dysfunction in adipocytes in response to immunosuppressive and antipsychotic drugs She is studying the effect of functional foods in combating insulin resistance and inflammation, to protect from these chronic diseases.

Moreover, she is also evaluating wound healing and tissue regeneration in diabetes, with the goal of enhancing early diagnosis of subjects at risk for chronic complications in order to personalize treatment. She is assessing the role of microRNAs and antimicrobial peptides in animal models of diabetic wound healing and infection. Dr. Carvalho and her team are advocates of Health Literacy for the public.

She has published over 80 scientific papers (h-index=37; >4000 citations; google scholar). She has mentored: Post-Docs (>20); PhDs (10); Master/Erasmus students (>20) and she has obtained >30 travel fellowships from the European Foundation for the Study of Diabetes (EFSD) for young students. She has secured funding: Europe (H2020-MSCA-ITN-2016 TREATMENT; EFSD; Diabetes UK); NIH (NIGMS-NIH P20GM109096; Pepper Older American Independence Centers; ABI); National (INFARMED; FCT; SPD; SPT). She is a board member: European Tissue Repair Society, senior editor: J of Endocrinology; J Mol Endocrinology, and reviewer for >40 journals and funding agencies: MRC UK; Israel Sci F; FONDECYT/CONACYT; FWF Der Wissenschaftsfonds; Wellcome Trust; Diabetes UK; French ANR. https://www.ncbi.nlm.nih.gov/myncbi/1N_kjxvZYzSAP/bibliography/public/

Main research lines:
1 - Metabolism across the lifespan;
2 - Wound healing and tissue regeneration
3 - Oxidative capacity of circulating cells and tissues
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Results 1-25 of 25 (Search time: 0.027 seconds).

Issue DateTitleAuthor(s)TypeAccess
12023Are Dietary Sugars Potent Adipose Tissue and Immune Cell Modulators?Barbosa, Pedro ; Carvalho, Eugenia articleopenAccess
217-Dec-2021Bioactive Antimicrobial Peptides as Therapeutic Agents for Infected Diabetic Foot UlcersDa Silva, Jessica; Leal, Ermelindo C. ; Carvalho, Eugenia articleopenAccess
32023Bioactive Ingredients in Traditional Fermented Food Condiments: Emerging Products for Prevention and Treatment of Obesity and Type 2 DiabetesLaya, Alphonse ; Wangso, Honoré; Fernandes, Iva; Djakba, Raphaël; Oliveira, Joana; Carvalho, Eugenia articleopenAccess
41-Jan-2023Circulating microRNA levels differ in the early stages of insulin resistance in prepubertal children with obesitySantos, Diana ; Porter-Gill, Patricia; Goode, Grace; Delhey, Leanna; Sørensen, Anja Elaine; Rose, Shannon; Børsheim, Elisabet; Dalgaard, Louise Torp; Carvalho, Eugenia articleopenAccess
57-Mar-2013Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best markerNunes, Sara ; Soares, Edna ; Fernandes, João ; Viana, Sofia D. ; Carvalho, Eugenia ; Pereira, Frederico C. ; Reis, Flávio articleopenAccess
62019Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse ModelSilva, Carolina; Sampaio-Pinto, Vasco; Andrade, Sara ; Rodrigues, Ilda; Costa, Raquel; Guerreiro, Susana; Carvalho, Eugenia ; Pinto-do-Ó, Perpétua; Nascimento, Diana S; Soares, RaquelarticleopenAccess
721-Jun-2017Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose DietBurgeiro, Ana ; Cerqueira, Manuela G. ; Varela-Rodríguez, Bárbara M; Nunes, Sara ; Neto, Paula; Pereira, Frederico C. ; Reis, Flávio ; Carvalho, Eugenia articleopenAccess
825-Feb-2023Green Antimicrobials as Therapeutic Agents for Diabetic Foot UlcersTeixeira, Inês D. ; Carvalho, Eugenia ; Leal, Ermelindo C. articleopenAccess
912-Mar-2021Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiotaMouritzen, Michelle V.; Petkovic, Marija ; Qvist, Katrine; Poulsen, Steen S.; Alarico, Susana ; Leal, Ermelindo C. ; Dalgaard, Louise T.; Empadinhas, Nuno ; Carvalho, Eugenia ; Jenssen, HåvardarticleopenAccess
108-Jun-2023Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot UlcersSilva, Jéssica da ; Leal, Ermelindo C. ; Carvalho, Eugenia ; Silva, Eduardo AarticleopenAccess
112-Oct-2020Mechanistic Actions of microRNAs in Diabetic Wound HealingPetkovic, Marija ; Sørensen, Anja Elaine; Leal, Ermelindo Carreira ; Carvalho, Eugenia ; Dalgaard, Louise TorparticleopenAccess
122017Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment StrategiesPereira, Sónia G. ; Moura, João ; Carvalho, Eugenia ; Empadinhas, Nuno articleopenAccess
139-Apr-2019microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammationMoura, João ; Sørensen, Anja; Leal, Ermelindo ; Svendsen, Rikke; Carvalho, Lina ; Willemoes, Rie Juul; Jørgensen, Per Trolle; Jenssen, Håvard; Wengel, Jesper; Dalgaard, Louise Torp; Carvalho, Eugenia articleopenAccess
1429-Sep-2020Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young MiceJun, Se-Ran; Cheema, Amrita; Bose, Chhanda; Boerma, Marjan; Palade, Philip T.; Carvalho, Eugenia ; Awasthi, Sanjay; Singh, Sharda P.articleopenAccess
152020Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milkCarvalho, Eugenia ; Adams, Sean H; Børsheim, Elisabet; Blackburn, Michael L; Ono-Moore, Kikumi D; Cotter, Matthew; Bowlin, Anne K; Yeruva, LaxmiarticleopenAccess
162014Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expressionSilva, Lucília Pereira da ; Neves, Bruno Miguel ; Moura, Liane I. F. ; Cruz, M. Teresa Girão da ; Carvalho, Eugenia articleopenAccess
172013Neurotensin modulates the migratory and inflammatory response of macrophages under hyperglycemic conditionsMoura, Liane I. F. ; Silva, Lucília ; Leal, Ermelindo C. ; Tellechea, Ana ; Cruz, Maria Teresa ; Carvalho, Eugenia articleopenAccess
182021Redox Imbalance and Methylation Disturbances in Early Childhood ObesityBarbosa, Pedro ; Melnyk, Stepan; Bennuri, Sirish C; Delhey, Leanna; Reis, Andreia ; Moura, Gabriela R; Børsheim, Elisabet; Rose, Shannon; Carvalho, Eugenia articleopenAccess
19Nov-2017Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older AdultsMarquis, Bryce J; Hurren, Nicholas M; Carvalho, Eugenia ; Kim, Il-Young; Schutzler, Scott; Azhar, Gohar; Wolfe, Robert R; Børsheim, ElisabetarticleopenAccess
20Nov-2020Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signalingBose, Chhanda; Alves, Inês ; Singh, Preeti; Palade, Philip T.; Carvalho, Eugenia ; Børsheim, Elisabet; Jun, Se-Ran; Cheema, Amrita; Boerma, Marjan; Awasthi, Sanjay; Singh, Sharda P.articleopenAccess
212015The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A "Me Too" or "the Special One" Antidiabetic Class?Godinho, Ricardo ; Mega, Cristina ; Teixeira-Lemos, Edite ; Carvalho, Eugenia ; Teixeira, Frederico ; Fernandes, Rosa ; Reis, Flávio articleopenAccess
2229-Sep-2014The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound HealingMoura, João ; Børsheim, Elisabet; Carvalho, Eugenia articleopenAccess
2317-Feb-2022The Role of Nutraceutical Containing Polyphenols in Diabetes PreventionFernandes, Iva; Oliveira, Joana; Pinho, Aryane ; Carvalho, Eugenia articleopenAccess
2414-Oct-2021Tracing Hepatic Glycogen and Lipid Metabolism with Stable Isotope Tracers: Insight From Murine StudiesDi Nunzio, GiadadoctoralThesisopenAccess
2520-May-2014Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat modelSereno, José ; Rodrigues-Santos, Paulo ; Vala, Helena; Rocha-Pereira, Petronila ; Alves, Rui; Fernandes, João; Santos-Silva, Alice; Carvalho, Eugenia ; Teixeira, Frederico ; Reis, F. articleopenAccess