Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/106520
Title: An Anthocyanin-Rich Extract Obtained from Portuguese Blueberries Maintains Its Efficacy in Reducing Microglia-Driven Neuroinflammation after Simulated Digestion
Authors: Serra, Diana 
Henriques, Joana F. 
Serra, Teresa
Silva, Andreia Bento
Bronze, Maria Rosário
Dinis, Teresa C. P. 
Almeida, Leonor M. 
Keywords: neuroinflammation; anthocyanins; phenolic acids; in vitro digestion; microglia; NF-kB; STAT1; ROS
Issue Date: 28-Nov-2020
Publisher: MDPI
Project: POCI-01-0145-FEDER-029089 (Anthocyanins4ASD) 
PTDC/SAU-NUT/29089/2017 
UIDB/04539/2020 
LISBOA-01-0145-FEDER-402-022125 
Serial title, monograph or event: Nutrients
Volume: 12
Issue: 12
Abstract: Dietary polyphenols are multi-target compounds that have been considered promising candidates in strategies for the mitigation of neurological diseases, acting particularly through reduction of microglia-driven neuroinflammation. In this study, an anthocyanin-rich extract obtained from Portuguese blueberries was subjected to a simulated gastrointestinal digestion; after chemical characterisation, the potential of both non-digested and digested extracts to combat neuroinflammation was evaluated using a microglia N9 cell line. Although the extracts have markedly different chemical composition, both were efficient in reducing the production of either key inflammatory markers or reactive oxygen species and in enhancing reduced glutathione levels in activated cells. Furthermore, this protection was shown to be related to the suppression of nuclear factor kappa B (NF-kB) activation, and to a signal transducer and activator of transcription 1 (STAT1)-independent mechanism. These results demonstrate that the anthocyanin extract, after simulated digestion, maintains its efficacy against neuroinflammation, and can, therefore, assume a relevant role in prevention of neuroinflammation-related neurological disorders.
URI: https://hdl.handle.net/10316/106520
ISSN: 2072-6643
DOI: 10.3390/nu12123670
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

Show full item record

Page view(s)

66
checked on May 29, 2024

Download(s)

19
checked on May 29, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons