Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/103690
Title: Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects
Authors: Dewaeles, Edmone
Carvalho, Kévin
Fellah, Sandy
Sim, Jaewon
Boukrout, Nihad
Caillierez, Raphaelle
Ramakrishnan, Hariharan
Van der Hauwaert, Cynthia
Vijaya Shankara, Jhenkruthi
Martin, Nathalie
Massri, Noura
Launay, Agathe
Folger, Joseph K
Schutter, Clémentine de
Larrue, Romain
Loison, Ingrid
Goujon, Marine
Jung, Matthieu
Le Gras, Stéphanie
Gomez-Murcia, Victoria
Faivre, Emilie
Lemaire, Julie
Garat, Anne
Beauval, Nicolas
Maboudou, Patrice
Gnemmi, Viviane
Gibier, Jean-Baptiste
Buée, Luc
Abbadie, Corinne
Glowacki, Francois
Pottier, Nicolas
Perrais, Michael
Cunha, Rodrigo A. 
Annicotte, Jean-Sébastien
Laumet, Geoffroy
Blum, David
Cauffiez, Christelle
Keywords: G protein–coupled receptors; Nephrology; Pharmacology
Issue Date: 15-Nov-2022
Serial title, monograph or event: The Journal of Clinical Investigation
Volume: 132
Issue: 22
Abstract: Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity. In the present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from cisplatin-induced nephrotoxicity and neuropathic pain in mice with or without tumors. Moreover, we also demonstrate that the antitumoral properties of cisplatin were not altered by istradefylline in tumor-bearing mice and could even be potentiated. Altogether, our results support the use of istradefylline as a valuable preventive approach for the clinical management of patients undergoing cisplatin treatment.
URI: https://hdl.handle.net/10316/103690
ISSN: 1558-8238
DOI: 10.1172/JCI152924
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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