Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/103690
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Dewaeles, Edmone | - |
dc.contributor.author | Carvalho, Kévin | - |
dc.contributor.author | Fellah, Sandy | - |
dc.contributor.author | Sim, Jaewon | - |
dc.contributor.author | Boukrout, Nihad | - |
dc.contributor.author | Caillierez, Raphaelle | - |
dc.contributor.author | Ramakrishnan, Hariharan | - |
dc.contributor.author | Van der Hauwaert, Cynthia | - |
dc.contributor.author | Vijaya Shankara, Jhenkruthi | - |
dc.contributor.author | Martin, Nathalie | - |
dc.contributor.author | Massri, Noura | - |
dc.contributor.author | Launay, Agathe | - |
dc.contributor.author | Folger, Joseph K | - |
dc.contributor.author | Schutter, Clémentine de | - |
dc.contributor.author | Larrue, Romain | - |
dc.contributor.author | Loison, Ingrid | - |
dc.contributor.author | Goujon, Marine | - |
dc.contributor.author | Jung, Matthieu | - |
dc.contributor.author | Le Gras, Stéphanie | - |
dc.contributor.author | Gomez-Murcia, Victoria | - |
dc.contributor.author | Faivre, Emilie | - |
dc.contributor.author | Lemaire, Julie | - |
dc.contributor.author | Garat, Anne | - |
dc.contributor.author | Beauval, Nicolas | - |
dc.contributor.author | Maboudou, Patrice | - |
dc.contributor.author | Gnemmi, Viviane | - |
dc.contributor.author | Gibier, Jean-Baptiste | - |
dc.contributor.author | Buée, Luc | - |
dc.contributor.author | Abbadie, Corinne | - |
dc.contributor.author | Glowacki, Francois | - |
dc.contributor.author | Pottier, Nicolas | - |
dc.contributor.author | Perrais, Michael | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Annicotte, Jean-Sébastien | - |
dc.contributor.author | Laumet, Geoffroy | - |
dc.contributor.author | Blum, David | - |
dc.contributor.author | Cauffiez, Christelle | - |
dc.date.accessioned | 2022-11-21T14:37:49Z | - |
dc.date.available | 2022-11-21T14:37:49Z | - |
dc.date.issued | 2022-11-15 | - |
dc.identifier.issn | 1558-8238 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/103690 | - |
dc.description.abstract | Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent medical need to identify novel strategies that limit cisplatin-induced toxicity. In the present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002) protected from cisplatin-induced nephrotoxicity and neuropathic pain in mice with or without tumors. Moreover, we also demonstrate that the antitumoral properties of cisplatin were not altered by istradefylline in tumor-bearing mice and could even be potentiated. Altogether, our results support the use of istradefylline as a valuable preventive approach for the clinical management of patients undergoing cisplatin treatment. | pt |
dc.language.iso | eng | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | G protein–coupled receptors | pt |
dc.subject | Nephrology | pt |
dc.subject | Pharmacology | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Cisplatin | pt |
dc.subject.mesh | Purines | pt |
dc.subject.mesh | Receptor, Adenosine A2A | pt |
dc.subject.mesh | Neuralgia | pt |
dc.subject.mesh | Antineoplastic Agents | pt |
dc.title | Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects | pt |
dc.type | article | - |
degois.publication.issue | 22 | pt |
degois.publication.title | The Journal of Clinical Investigation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1172/JCI152924 | pt |
degois.publication.volume | 132 | pt |
dc.date.embargo | 2022-11-15 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairetype | article | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Istradefylline protects from cisplatin-induced nephrotoxicity.pdf | 10.84 MB | Adobe PDF | Ver/Abrir |
Visualizações de página
95
Visto em 17/jul/2024
Downloads
35
Visto em 17/jul/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons