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| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 2006 | β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study | Milhazes, Nuno ; Calheiros, Rita ; Marques, M. Paula M. ; Garrido, Jorge ; Cordeiro, M. Natália D. S. ; Rodrigues, Cátia ; Quinteira, Sandra ; Novais, Carla ; Peixe, Luísa ; Borges, Fernanda | article | openAccess |
| 2 | 2008 | Biological activity of antitumoural MGBG: the structural variable | Marques, M. P. M. ; Gil, F. ; Calheiros, R. ; Battaglia, V. ; Brunati, A. ; Agostinelli, E. ; Toninello, A. | article | openAccess |
| 3 | 20-May-2004 | Cytotoxic Activity of Metal Complexes of Biogenic Polyamines: Polynuclear Platinum(II) Chelates | Teixeira, Luísa J. ; Seabra, Marta ; Reis, Elisa ; Cruz, M. Teresa Girão da ; Lima, M. Conceição Pedroso de ; Pereira, Eulália ; Miranda, M. Adelaide ; Marques, M. Paula M. | article | openAccess |
| 4 | 16-Mar-2021 | Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease | Queda, Fausto; Calò, Sonia; Gwizdala, Karolina; Magalhães, João D. ; Cardoso, Sandra M. ; Chaves, Sílvia; Piemontese, Luca; Santos, M. Amélia | article | openAccess |
| 5 | 29-Apr-2020 | Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity | Sousa, Cátia ; Leitão, Alcino Jorge ; Neves, Bruno Miguel ; Judas, Fernando ; Cavaleiro, Carlos ; Mendes, Alexandrina F. | article | openAccess |
| 6 | 25-Mar-2020 | Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A | Morais, Thiago R.; Conserva, Geanne A. Alves; Varela, Marina T.; Costa-Silva, Thais A.; Thevenard, Fernanda; Ponci, Vitor; Fortuna, Ana ; Falcão, Amílcar C. ; Tempone, Andre G.; Fernandes, João Paulo S. ; Lago, João Henrique G. | article | openAccess |
| 7 | 27-Mar-2019 | A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods | Bueschbell, Beatriz ; Barreto, Carlos A. V. ; Preto, Antonio J. ; Schiedel, Anke C.; Moreira, Irina S. | article | openAccess |
| 8 | 7-Feb-2019 | New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease | Rajeshwari, Rajeshwari; Chand, Karam; Candeias, Emanuel ; Cardoso, Sandra M. ; Chaves, Sílvia; Santos, M. Amélia | article | openAccess |
| 9 | 2-Dec-2019 | Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues | Chavarria, Daniel ; Fernandes, Carlos; Aguiar, Brandon; Silva, Tiago ; Garrido, Jorge ; Remião, Fernando ; Oliveira, Paulo J. ; Uriarte, Eugenio ; Borges, Fernanda | article | openAccess |
| 10 | 23-Dec-2018 | Less Exploited GPCRs in Precision Medicine: Targets for Molecular Imaging and Theranostics | Machado, João Franco; Silva, Rúben D.; Melo, Rita ; Correia, João D. G. | article | openAccess |
| 11 | 17-Jun-2008 | Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: Relevance to the length of the alkoxyl chain in positions 3 and 5 of the DHP ring | Fernandes, Maria A. S. ; Pereira, Susana P. S. ; Jurado, Amália S. ; Custódio, José B. A. ; Santos, Maria S. ; Moreno, António J. M. ; Duburs, Gunars ; Vicente, Joaquim A. F. | article | openAccess |
| 12 | 2005 | Structure–property studies on the antioxidant activity of flavonoids present in diet | Teixeira, Susana ; Siquet, Christophe ; Alves, Carla ; Boal, Isabel ; Marques, M. Paula ; Borges, Fernanda ; Lima, José L. F. C. ; Reis, Salette | article | openAccess |
| 13 | 2008 | Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives - A New Paradigm in Phenolic Research | Esteves, Mário ; Siquet, Christophe ; Gaspar, Alexandra ; Rio, Vitor ; Sousa, Joana B. ; Reis, Salette ; Marques, M. Paula M. ; Borges, Fernanda | article | openAccess |
| 14 | 2003 | Anticancer Activity of Phenolic Acids of Natural or Synthetic Origin: A Structure−Activity Study | Gomes, Catarina A. ; Cruz, Teresa Girão da ; Andrade, José L. ; Milhazes, Nuno ; Borges, Fernanda ; Marques, M. Paula M. | article | openAccess |
| 15 | 2004 | Phenolic acid derivatives with potential anticancer properties––a structure–activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acids | Fiuza, S. M. ; Gomes, C. ; Teixeira, L. J. ; Girão da Cruz, M. T. ; Cordeiro, M. N. D. S. ; Milhazes, N. ; Borges, F. ; Marques, M. P. M. | article | openAccess |
| 16 | 24-Jun-2020 | Synthesis of Iron(II)-N-Heterocyclic Carbene Complexes: Paving the Way for a New Class of Antibiotics | Vinagreiro, Carolina dos Santos ; Lopes, Rita; Royo, Beatriz; Silva, Gabriela Jorge da ; Pereira, Mariette M. | article | openAccess |
| 17 | Dec-2020 | Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease | Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F. ; Cardoso, Sandra M. ; Chaves, Sílvia; Santos, M. Amélia | article | openAccess |
| 18 | 6-Mar-2020 | Structure and Aggregation Mechanisms in Amyloids | Almeida, Zaida L. ; Brito, Rui M. M. | article | openAccess |
| 19 | 22-Feb-2020 | Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease | Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; Capriati, Vito; Santos, A. Raquel Pereira ; Cardoso, Sandra M. ; Santos, M. Amélia | article | openAccess |
| 20 | Dec-2018 | Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates | Piemontese, Luca; Tomás, Daniel; Hiremathad, Asha; Capriati, Vito; Candeias, Emanuel ; Cardoso, Sandra M. ; Chaves, Sílvia; Santos, M. Amélia | article | openAccess |
| 21 | 2017 | Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies | Pucelik, Barbara; Paczyński, Robert; Dubin, Grzegorz; Pereira, Mariette M. ; Arnaut, Luís G. ; Dąbrowski, Janusz M. | article | openAccess |
| 22 | 2017 | Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach | Baptista, Salete J. ; Silva, Maria M. C. ; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio ; Dinis, Teresa C. P. ; Salvador, Jorge A. R. | article | openAccess |
| 23 | 18-Feb-2016 | Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation | Blondel, S.; Egesipe, A-L; Picardi, P.; Jaskowiak, A-L; Notarnicola, M.; Ragot, J.; Tournois, J.; Le Corf, A.; Brinon, B.; Poydenot, P.; Georges, P.; Navarro, C.; Pitrez, P. R. ; Ferreira, L. ; Bollot, G.; Bauvais, C.; Laustriat, D.; Mejat, A.; De Sandre-Giovannoli, A.; Levy, N.; Bifulco, M.; Peschanski, M.; Nissan, X. | article | openAccess |
| 24 | 30-Nov-2015 | Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism | Mendes, Vítor ; Blaszczyk, Michal; Maranha, Ana ; Empadinhas, Nuno ; Blundell, Tom L. | article | openAccess |
| 25 | Dec-2010 | Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy | Hafner, Angela V. ; Dai, Jing ; Gomes, Ana P. ; Xiao, Chun-Yang ; Palmeira, Carlos M. ; Rosenzweig, Anthony; Sinclair, David A. | article | openAccess |
| 26 | 15-Aug-2020 | Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer | Laranjo, Mafalda ; Aguiar, Márcia Campos ; Pereira, Nelson A. M. ; Brites, Gonçalo; Nascimento, Bruno F. O. ; Brito, Ana F. ; Casalta-Lopes, João ; Gonçalves, Ana Cristina ; Sarmento-Ribeiro, Ana Bela ; Piñeiro Gomez, Marta ; Botelho, Maria Filomena ; Melo, Teresa M. V. D. Pinho e | article | embargoedAccess |
| 27 | 5-Jul-2021 | Synthesis and structure-activity relationships of new chiral spiro-β-lactams highly active against HIV-1 and Plasmodium | Alves, Nuno Guerreiro ; Bártolo, Inês; Alves, Américo J. S. ; Fontinha, Diana; Francisco, Denise; Lopes, Susana M. M.; Soares, Maria I. L. ; Simões, Carlos J. V. ; Prudêncio, Miguel ; Taveira, Nuno; Pinho e Melo, Teresa M. V. D. | article | embargoedAccess |
| 28 | Dec-2018 | Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid | Teixeira, José ; Oliveira, Catarina; Cagide, Fernando; Amorim, Ricardo ; Garrido, Jorge ; Borges, Fernanda; Oliveira, Paulo J. | article | openAccess |
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