Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7581
Title: Biological activity of antitumoural MGBG: the structural variable
Authors: Marques, M. P. M. 
Gil, F. 
Calheiros, R. 
Battaglia, V. 
Brunati, A. 
Agostinelli, E. 
Toninello, A. 
Issue Date: 2008
Issue Date: 2008
Citation: Amino Acids. 34:4 (2008) 555-564
Abstract: Abstract The present study aims at determining the structure-activity relationships (SAR’s) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-l-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG’s structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.
URI: http://hdl.handle.net/10316/7581
DOI: 10.1007/s00726-007-0009-2
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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