Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/7581
DC FieldValueLanguage
dc.contributor.authorMarques, M. P. M.-
dc.contributor.authorGil, F.-
dc.contributor.authorCalheiros, R.-
dc.contributor.authorBattaglia, V.-
dc.contributor.authorBrunati, A.-
dc.contributor.authorAgostinelli, E.-
dc.contributor.authorToninello, A.-
dc.date.accessioned2009-02-17T10:18:59Z-
dc.date.available2009-02-17T10:18:59Z-
dc.date.issued2008-
dc.identifier.citationAmino Acids. 34:4 (2008) 555-564-
dc.identifier.urihttps://hdl.handle.net/10316/7581-
dc.description.abstractThe present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-L-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.-
dc.language.isoeng-
dc.rightsopenAccess-
dc.subjectAdenosylmethionine Decarboxylase-
dc.subjectAnimals-
dc.subjectAntineoplastic Agents-
dc.subjectBinding Sites-
dc.subjectCalcium-
dc.subjectCell Membrane Permeability-
dc.subjectComputer Simulation-
dc.subjectDose-Response Relationship, Drug-
dc.subjectEnzyme Inhibitors-
dc.subjectHepatocytes-
dc.subjectHydrogen-Ion Concentration-
dc.subjectMale-
dc.subjectMitochondria, Liver-
dc.subjectMitoguazone-
dc.subjectModels, Molecular-
dc.subjectQuantum Theory-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectSpermidine-
dc.subjectSpermine-
dc.subjectStructure-Activity Relationship-
dc.subjectTime Factors-
dc.subjectModels, Biological-
dc.titleBiological activity of antitumoural MGBG: the structural variable-
dc.typearticle-
degois.publication.firstPage555-
degois.publication.lastPage564-
degois.publication.issue4-
degois.publication.titleAmino Acids-
dc.peerreviewedyes-
dc.identifier.doi10.1007/s00726-007-0009-2-
degois.publication.volume34-
uc.controloAutoridadeSim-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.researchunitQFM-UC – Molecular Physical-Chemistry R&D Unit-
crisitem.author.researchunitCFisUC – Center for Physics of the University of Coimbra-
crisitem.author.orcid0000-0002-8391-0055-
crisitem.author.orcid0000-0001-7546-0288-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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