Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/7581
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dc.contributor.authorMarques, M. P. M.-
dc.contributor.authorGil, F.-
dc.contributor.authorCalheiros, R.-
dc.contributor.authorBattaglia, V.-
dc.contributor.authorBrunati, A.-
dc.contributor.authorAgostinelli, E.-
dc.contributor.authorToninello, A.-
dc.date.accessioned2009-02-17T10:18:59Z-
dc.date.available2009-02-17T10:18:59Z-
dc.date.issued2008en_US
dc.identifier.citationAmino Acids. 34:4 (2008) 555-564en_US
dc.identifier.urihttp://hdl.handle.net/10316/7581-
dc.description.abstractAbstract The present study aims at determining the structure-activity relationships (SAR’s) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-l-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG’s structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleBiological activity of antitumoural MGBG: the structural variableen_US
dc.typearticleen_US
dc.identifier.doi10.1007/s00726-007-0009-2en_US
uc.controloAutoridadeSim-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.deptFaculdade de Ciências e Tecnologia, Universidade de Coimbra-
crisitem.author.parentdeptUniversidade de Coimbra-
crisitem.author.researchunitCenter for Physics, University of Coimbra-
crisitem.author.orcid0000-0001-7546-0288-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
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