Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/45150
Title: Phenolic acid derivatives with potential anticancer properties––a structure–activity relationship study. Part 1: Methyl, propyl and octyl esters of caffeic and gallic acids
Authors: Fiuza, S.M. 
Gomes, C. 
Teixeira, L.J. 
Girão da Cruz, M.T. 
Cordeiro, M.N.D.S. 
Milhazes, N. 
Borges, F. 
Marques, M.P.M. 
Keywords: Antineoplastic Agents; Caffeic Acids; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Esters; Gallic Acid; Humans; Hydroxybenzoates; Inhibitory Concentration 50; Methylation; Molecular Structure; Structure-Activity Relationship
Issue Date: 2004
Keywords: Antineoplastic Agents; Caffeic Acids; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Esters; Gallic Acid; Humans; Hydroxybenzoates; Inhibitory Concentration 50; Methylation; Molecular Structure; Structure-Activity Relationship
Issue Date: 2004
Abstract: The antiproliferative and cytotoxic properties of polyphenolic acid derivatives, structurally related with the natural models caffeic and gallic acids, have been tested in human cervix adenocarcinoma cells (HeLa). Simultaneous structural information was obtained for these compounds through theoretical ab initio methods. This study was conducted for the following esters: methyl caffeate (MC, 1), propyl caffeate (PC, 2), octyl caffeate (OC, 3), methyl gallate (MG, 4), propyl gallate (PG, 5) and octyl gallate (OG, 6). A significant growth-inhibition effect was assessed for some of these compounds, clearly dependent on their structural characteristics. Marked structure-activity relationships (SARs)--namely the number of hydroxyl ring substituents--were found to rule the biological effect of such systems.
URI: http://hdl.handle.net/10316/45150
Other Identifiers: 10.1016/j.bmc.2004.04.026
DOI: 10.1016/j.bmc.2004.04.026
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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