info:eu-repo/grantAgreement/H2020/722619/EU/MarieSkłodowska-Curie/FOIEGRAS

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Primary Data

Project title
info:eu-repo/grantAgreement/H2020/722619/EU/MarieSkłodowska-Curie/FOIEGRAS
Code
Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
Organization
 
Status
On going
Start date
01-01-2017
Expected Completion
30-06-2021
 

Description

Abstract
FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of Europea
 
Keyword(s)
MSCA-ITN-2016 - Innovative Training Networks

Publications
(Todas)

Resultados 1-17 de 17.

Data de publicaçãoTítuloAutor(es)TipoAcesso
115-Jan-2021Adiponectin involved in portal flow hepatic extraction of 13C-metacethin in obesity and non-alcoholic fatty liverDi Ciaula, Agostino; Carbone, Federico; Shanmugham, Harshitha; Molina-Molina, Emilio; Bonfrate, Leonilde; Ministrini, Stefano; Montecucco, Fabrizio; Portincasa, PieroarticleembargoedAccess
222-Ago-2018Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia InjuryPanisello-Roselló, Arnau; Alva, Norma; Flores, Marta; Lopez, Alexandre ; Castro Benítez, Carlos; Folch-Puy, Emma; Rolo, Anabela ; Palmeira, Carlos ; Adam, René ; Carbonell, Teresa ; Roselló-Catafau, Joan articleopenAccess
3Mar-2021Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean dietCarbone, Federico; Ciaula, Agostino Di; Pagano, Sabrina; Minetti, Silvia; Ansaldo, Anna Maria; Ferrara, Daniele; Belfiore, Anna; Elia, Edoardo; Pugliese, Stefania; Ostilio Palmieri, Vincenzo; Montecucco, Fabrizio; Vuilleumier, Nicolas; Portincasa, PieroarticleembargoedAccess
416-Ago-2019Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver DiseaseFontes, Adriana ; Alemany-Pagès, Mireia; Oliveira, Paulo J. ; Ramalho-Santos, João ; Zischka, Hans; Azul, Anabela Marisa articleopenAccess
5Dez-2020Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in miceDiNunzio, Giada ; Belew, Getachew D.; Torres, Alejandra N.; Silva, Joao Gabriel; Silva, Luís P.; Barosa, Cristina ; Tavares, Ludgero ; Jones, John G. articleopenAccess
6Abr-2020Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U-13 C]fructose and [U-13 C]glucoseBelew, Getachew D.; Di Nunzio, Giada; Tavares, Ludgero ; Silva, Joao G.; Torres, Alejandra N.; Jones, John Griffith articleembargoedAccess
719-Mai-2021Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 CellsAmorim, Ricardo ; Simões, Inês C. M.; Veloso, Caroline ; Carvalho, Adriana ; Simões, Rui F. ; Pereira, Francisco B. ; Thiel, Theresa; Normann, Andrea; Morais, Catarina M. ; Jurado, Maria Amália da Silva ; Wieckowski, Mariusz R. ; Teixeira, José ; Oliveira, Paulo J. articleopenAccess
812-Jan-2023Gestational Exercise Antagonises the Impact of Maternal High-Fat High-Sucrose Diet on Liver Mitochondrial Alterations and Quality Control Signalling in Male OffspringStevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Oliveira, Paulo J. ; Ascensão, António ; Magalhães, JoséarticleopenAccess
9Abr-2018Graft Protection Against Cold Ischemia Preservation: An Institute George Lopez 1 and Histidine-tryptophan-ketoglutarate Solution AppraisalPanisello-Rosello, A; Castro-Benítez, C; Lopez, A; Balloji, S; Folch-Puy, E; Adam, R; Roselló-Catafau, JarticleembargoedAccess
108-Out-2021“A Healthy Liver Will Always Deliver” : Development of a Comic to Raise Awareness About Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Metabolic DisordersAlemany i Pagès, MireiadoctoralThesisembargoedAccess
11Jun-2020Mechanisms for increased risk of diabetes in chronic liver diseasesSvegliati-Baroni, Gianluca; Gaggini, Melania; Carli, Fabrizia; Barbieri, Chiara; Cucco, Monica; Youne, Ramy; Rosso, Chiara; Bugianesi, Elisabetta; Gastaldelli, AmaliaarticleembargoedAccess
122019A Mitochondrial Approach to Cardiovascular Risk and DiseaseVeloso, Caroline D. ; Belew, Getachew D.; Ferreira, Luciana L. ; Grilo, Luís F. ; Jones, John Griffith ; Portincasa, Piero; Sardão, Vilma A. ; Oliveira, Paulo J. articleembargoedAccess
13Fev-2019Targeting mitochondria to oppose the progression of nonalcoholic fatty liver diseaseGrattagliano, Ignazio; Montezinho, Liliana P. ; Oliveira, Paulo J. ; Frühbeck, Gema; Gómez-Ambrosi, Javier; Montecucco, Fabrizio; Carbone, Federico; Wieckowski, Mariusz R. ; Wang, David Q-H; Portincasa, PieroarticleembargoedAccess
14Out-2020The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspectiveSimoes, Ines C M; Morciano, Giampaolo; Lebiedzinska-Arciszewska, Magdalena; Aguiari, Gianluca; Pinton, Paolo; Potes, Yaiza; Wieckowski, Mariusz R. articleembargoedAccess
15Jan-2020The role of mitochondria-associated membranes in cellular homeostasis and diseasesPerrone, Mariasole; Caroccia, Natascia; Genovese, Ilaria; Missiroli, Sonia; Modesti, Lorenzo; Pedriali, Gaia; Vezzani, Bianca; Vitto, Veronica Angela Maria; Antenori, Michele; Lebiedzinska-Arciszewska, Magdalena; Wieckowski, Mariusz R. ; Giorgi, Carlotta; Pinton, PaolobookembargoedAccess
16Dez-2020The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetesGuerra, Sara Isabel da Silva ; Gastaldelli, AmaliaarticleembargoedAccess
1715-Out-2020Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic ResponseSimoes, Ines C M; Karkucinska-Wieckowska, Agnieszka; Janikiewicz, Justyna; Szymanska, Sylwia; Pronicki, Maciej; Dobrzyn, Pawel; Dabrowski, Michal; Dobrzyn, Agnieszka; Oliveira, Paulo J. ; Zischka, Hans; Potes, Yaiza; Wieckowski, Mariusz R. articleopenAccess