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Title: Fibrosis nonalcoholic steatohepatitis index validation and applicability considering glycaemic severity and T2D duration
Authors: Pina, Ana
Meneses, Maria João
Ribeiro, Rogério César de Almeida 
Raposo, João F
Macedo, Maria Paula 
Issue Date: Nov-2022
Project: PTDC/MEC-MET/29314/2017 
mtFOIE GRAS (734719) 
Volume: 42
Issue: 11
Abstract: Nonalcoholic fatty liver disease (NAFLD) diagnosis without using invasive methods is extremely challenging, highlighting the need for simple indexes for this end. Recently, the fibrotic nonalcoholic steatohepatitis index (FNI) was developed and proposed as an affordable non-invasive score calculated with aspartate aminotransferase, high-density lipoprotein cholesterol and haemoglobin A1c. Herein, and given the link between NAFLD and diabetes, we aimed at validating FNI in a population with type 2 diabetes (T2D), also considering diabetes duration and glycaemic severity. The performance of FNI was higher than FIB-4 (AUROC = 0.89 vs 0.67, respectively). Additionally, using 0.1 as the rule-out cut-off of FNI, the sensitivity was 0.99 and the positive predictive value was 0.19. Both duration of diabetes and A1c did not impact FNI performance. In sum, FNI is a valuable score for predicting fibrotic nonalcoholic steatohepatitis not only for primary care units but also for diabetes specialized care.
ISSN: 1478-3223
DOI: 10.1111/liv.15406
Rights: embargoedAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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