Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/107038
Title: | Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease | Authors: | Fontes, Adriana Alemany-Pagès, Mireia Oliveira, Paulo J. Ramalho-Santos, João Zischka, Hans Azul, Anabela Marisa |
Keywords: | mitochondria; non-alcoholic fatty liver disease; fungi; mushrooms; truffles; antioxidant; oxidative stress; lipid metabolism; apoptosis; NASH; HCC | Issue Date: | 16-Aug-2019 | Publisher: | MDPI | Project: | info:eu-repo/grantAgreement/H2020/722619/EU/MarieSkłodowska-Curie/FOIEGRAS | Serial title, monograph or event: | International Journal of Molecular Sciences | Volume: | 20 | Issue: | 16 | Abstract: | Mitochondria play a central role in non-alcoholic fatty liver disease (NAFLD) progression and in the control of cell death signalling during the progression to hepatocellular carcinoma (HCC). Associated with the metabolic syndrome, NAFLD is mostly driven by insulin-resistant white adipose tissue lipolysis that results in an increased hepatic fatty acid influx and the ectopic accumulation of fat in the liver. Upregulation of beta-oxidation as one compensatory mechanism leads to an increase in mitochondrial tricarboxylic acid cycle flux and ATP generation. The progression of NAFLD is associated with alterations in the mitochondrial molecular composition and respiratory capacity, which increases their vulnerability to different stressors, including calcium and pro-inflammatory molecules, which result in an increased generation of reactive oxygen species (ROS) that, altogether, may ultimately lead to mitochondrial dysfunction. This may activate further pro-inflammatory pathways involved in the progression from steatosis to steatohepatitis (NASH). Mushroom-enriched diets, or the administration of their isolated bioactive compounds, have been shown to display beneficial effects on insulin resistance, hepatic steatosis, oxidative stress, and inflammation by regulating nutrient uptake and lipid metabolism as well as modulating the antioxidant activity of the cell. In addition, the gut microbiota has also been described to be modulated by mushroom bioactive molecules, with implications in reducing liver inflammation during NAFLD progression. Dietary mushroom extracts have been reported to have anti-tumorigenic properties and to induce cell-death via the mitochondrial apoptosis pathway. This calls for particular attention to the potential therapeutic properties of these natural compounds which may push the development of novel pharmacological options to treat NASH and HCC. We here review the diverse effects of mushroom-enriched diets in liver disease, emphasizing those effects that are dependent on mitochondria. | URI: | https://hdl.handle.net/10316/107038 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms20163987 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Antioxidant-versus-proapoptotic-effects-of-mushroomenriched-diets-on-mitochondria-in-liver-diseaseInternational-Journal-of-Molecular-Sciences.pdf | 895.92 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
20
checked on Sep 16, 2024
WEB OF SCIENCETM
Citations
18
checked on Sep 2, 2024
Page view(s)
83
checked on Oct 9, 2024
Download(s)
18
checked on Oct 9, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License