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https://hdl.handle.net/10316/93152
Título: | Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation | Autor: | Ribeiro, Luís F. Catarino, Tatiana Carvalho, Mário Cortes, Luísa Santos, Sandra D. Opazo, Patricio O. Ribeiro, Lyn Rosenbrier Oliveiros, Bárbara Choquet, Daniel Esteban, José A. Peça, João Carvalho, Ana Luísa |
Data: | 2021 | Editora: | American Association for the Advancement of Science | Projeto: | IF/00812/2012 UIDB/04539/2020 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias |
Título da revista, periódico, livro ou evento: | Science Signaling | Volume: | 14 | Número: | 670 | Resumo: | The biological signals of hunger, satiety, and memory are interconnected. The role of the hormone ghrelin in regulating feeding and memory makes ghrelin receptors attractive targets for associated disorders. We investigated the effects of the high ligand-independent activity of the ghrelin receptor GHS-R1a on the physiology of excitatory synapses in the hippocampus. Blocking this activity produced a decrease in the synaptic content of AMPA receptors in hippocampal neurons and a reduction in GluA1 phosphorylation at Ser845. Reducing the ligand-independent activity of GHS-R1a increased the surface diffusion of AMPA receptors and impaired AMPA receptor–dependent synaptic delivery induced by chemical long-term potentiation. Accordingly, we found that blocking this GHS-R1a activity impaired spatial and recognition memory in mice. These observations support a role for the ligand-independent activity of GHS-R1a in regulating AMPA receptor trafficking under basal conditions and in the context of synaptic plasticity that underlies learning. | URI: | https://hdl.handle.net/10316/93152 | ISSN: | 1945-0877 1937-9145 |
DOI: | 10.1126/scisignal.abb1953 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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BrainHealth 2020-video.mp4 | 126.18 MB | Unknown | Ver/Abrir | |
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation_accepted version.pdf | 2.7 MB | Adobe PDF | Ver/Abrir |
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