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https://hdl.handle.net/10316/3799
Título: | Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels | Autor: | Ferreira, Lino Gil, Maria H. Cabrita, António M. S. Dordick, Jonathan S. |
Palavras-chave: | Dextran; Hydrogel; Cross-linking; Biodegradation | Data: | 2005 | Citação: | Biomaterials. 26:23 (2005) 4707-4716 | Resumo: | We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 [mu]m depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery. | URI: | https://hdl.handle.net/10316/3799 | DOI: | 10.1016/j.biomaterials.2004.11.051 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Eng.Química - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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filee77693454d454afeb776cd4b88edbd58.pdf | 561.61 kB | Adobe PDF | Ver/Abrir |
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