Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/3799
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreira, Lino | - |
dc.contributor.author | Gil, Maria H. | - |
dc.contributor.author | Cabrita, António M. S. | - |
dc.contributor.author | Dordick, Jonathan S. | - |
dc.date.accessioned | 2008-08-29T15:26:37Z | - |
dc.date.available | 2008-08-29T15:26:37Z | - |
dc.date.issued | 2005 | en_US |
dc.identifier.citation | Biomaterials. 26:23 (2005) 4707-4716 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/3799 | - |
dc.description.abstract | We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 [mu]m depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6TWB-4F7Y94V-3/1/0d83788c215a34850e13d6d76d3bba82 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Dextran | en_US |
dc.subject | Hydrogel | en_US |
dc.subject | Cross-linking | en_US |
dc.subject | Biodegradation | en_US |
dc.title | Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.biomaterials.2004.11.051 | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0001-8985-9302 | - |
crisitem.author.orcid | 0000-0001-5165-5849 | - |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais |
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filee77693454d454afeb776cd4b88edbd58.pdf | 561.61 kB | Adobe PDF | View/Open |
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