Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/3799
Title: | Biocatalytic synthesis of highly ordered degradable dextran-based hydrogels | Authors: | Ferreira, Lino Gil, Maria H. Cabrita, António M. S. Dordick, Jonathan S. |
Keywords: | Dextran; Hydrogel; Cross-linking; Biodegradation | Issue Date: | 2005 | Citation: | Biomaterials. 26:23 (2005) 4707-4716 | Abstract: | We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 [mu]m depending on the degree of substitution. In addition, the hydrogels show a higher elastic modulus for a given swelling ratio than chemically synthesized dextran-based hydrogels. In vivo studies in rats show that the hydrogel networks are degradable over a range of time scales from 5 to over 40 days, and possess good biocompatibility, as reflected in only a mild inflammatory reaction and minor fibrous capsule formation during the time-frame of subcutaneous implantation. These combined properties may offer competitive advantages in biomedical applications ranging from tissue engineering to controlled drug delivery. | URI: | https://hdl.handle.net/10316/3799 | DOI: | 10.1016/j.biomaterials.2004.11.051 | Rights: | openAccess |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
filee77693454d454afeb776cd4b88edbd58.pdf | 561.61 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.