Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27724
Title: | Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting | Authors: | Morais, G. Ribeiro Gano, L. Kniess, T. Bergmann, R. Abrunhosa, A. Santos, I. Paulo, A. |
Keywords: | Alzheimer′s Disease; β-Amyloid aggregation; Molecular imaging; Fluorine-18 | Issue Date: | Dec-2013 | Publisher: | Elsevier | Citation: | MORAIS, G. Ribeiro [et. al] - Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting. "Applied Radiation and Isotopes". ISSN 0969-8043. Vol. 82 (2013) p. 100-104 | Serial title, monograph or event: | Applied Radiation and Isotopes | Volume: | 82 | Abstract: | The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD. Herein, we describe the radiosynthesis of the radiofluorinated styryl benzoxazole derivative [18F]-[2-[N-methyl-N-(2′-fluoroethyl)-4′-aminostyryl]benzoxazole] ([18F]-1) and its pre-clinical evaluation, including metabolic and biodistribution studies in male Wistar rats. The in vivo biological evaluation of [18F]-1 showed that this new radiotracer has a moderate brain uptake with a slow brain washout and a poor in vivo stability. | URI: | https://hdl.handle.net/10316/27724 | ISSN: | 0969-8043 | DOI: | 10.1016/j.apradiso.2013.07.003 | Rights: | openAccess |
Appears in Collections: | I&D CIBIT - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Radiosynthesis and in vivo.pdf | 580.99 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.