Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27724
DC FieldValueLanguage
dc.contributor.authorMorais, G. Ribeiro-
dc.contributor.authorGano, L.-
dc.contributor.authorKniess, T.-
dc.contributor.authorBergmann, R.-
dc.contributor.authorAbrunhosa, A.-
dc.contributor.authorSantos, I.-
dc.contributor.authorPaulo, A.-
dc.date.accessioned2014-11-25T11:07:45Z-
dc.date.available2014-11-25T11:07:45Z-
dc.date.issued2013-12-
dc.identifier.citationMORAIS, G. Ribeiro [et. al] - Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting. "Applied Radiation and Isotopes". ISSN 0969-8043. Vol. 82 (2013) p. 100-104por
dc.identifier.issn0969-8043-
dc.identifier.urihttps://hdl.handle.net/10316/27724-
dc.description.abstractThe formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD. Herein, we describe the radiosynthesis of the radiofluorinated styryl benzoxazole derivative [18F]-[2-[N-methyl-N-(2′-fluoroethyl)-4′-aminostyryl]benzoxazole] ([18F]-1) and its pre-clinical evaluation, including metabolic and biodistribution studies in male Wistar rats. The in vivo biological evaluation of [18F]-1 showed that this new radiotracer has a moderate brain uptake with a slow brain washout and a poor in vivo stability.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectAlzheimer′s Diseasepor
dc.subjectβ-Amyloid aggregationpor
dc.subjectMolecular imagingpor
dc.subjectFluorine-18por
dc.titleRadiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targetingpor
dc.typearticlepor
degois.publication.firstPage100por
degois.publication.lastPage104por
degois.publication.titleApplied Radiation and Isotopespor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0969804313002923por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.apradiso.2013.07.003-
degois.publication.volume82por
item.languageiso639-1en-
item.openairetypearticle-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
item.cerifentitytypePublications-
crisitem.author.researchunitICNAS - Institute for Nuclear Sciences Applied to Health-
crisitem.author.orcid0000-0002-4145-854X-
Appears in Collections:I&D CIBIT - Artigos em Revistas Internacionais
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