Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27724
Title: Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting
Authors: Morais, G. Ribeiro 
Gano, L. 
Kniess, T. 
Bergmann, R. 
Abrunhosa, A. 
Santos, I. 
Paulo, A. 
Keywords: Alzheimer′s Disease; β-Amyloid aggregation; Molecular imaging; Fluorine-18
Issue Date: Dec-2013
Publisher: Elsevier
Citation: MORAIS, G. Ribeiro [et. al] - Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting. "Applied Radiation and Isotopes". ISSN 0969-8043. Vol. 82 (2013) p. 100-104
Serial title, monograph or event: Applied Radiation and Isotopes
Volume: 82
Abstract: The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD. Herein, we describe the radiosynthesis of the radiofluorinated styryl benzoxazole derivative [18F]-[2-[N-methyl-N-(2′-fluoroethyl)-4′-aminostyryl]benzoxazole] ([18F]-1) and its pre-clinical evaluation, including metabolic and biodistribution studies in male Wistar rats. The in vivo biological evaluation of [18F]-1 showed that this new radiotracer has a moderate brain uptake with a slow brain washout and a poor in vivo stability.
URI: http://hdl.handle.net/10316/27724
ISSN: 0969-8043
DOI: 10.1016/j.apradiso.2013.07.003
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais

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