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Title: In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment
Authors: Natu, Mădălina V. 
Gaspar, Manuel N. 
Ribeiro, Carlos A. Fontes 
Cabrita, António M. 
Sousa, Hermínio C. de 
Gil, M. H. 
Keywords: Poly(ɛ-caprolactone); Subconjunctival implant; Controlled drug release; In vivo; Intraocular pressure; Glaucoma
Issue Date: Jul-2011
Publisher: Elsevier
Citation: NATU, Mădălina V. [et al.] - In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment. "International Journal of Pharmaceutics". ISSN 0378-5173. 415:1–2 (2011) 73-82
Serial title, monograph or event: International Journal of Pharmaceutics
Volume: 415
Issue: 1-2
Abstract: Implantable disks for glaucoma treatment were prepared by blending poly(ɛ-caprolactone), PCL, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) and dorzolamide. Their in vivo performance was assessed by their capacity to decrease intraocular pressure (IOP) in normotensive and hypertensive eyes. Drug mapping showed that release was complete from blend disks and the low molecular weight (MW) PCL after 1 month in vivo. The high MW PCL showed non-cumulative release rates above the therapeutic level during 3 months in vitro. In vivo, the fibrous capsule formation around the implant controls the drug release, working as a barrier membrane. Histologic analysis showed normal foreign body reaction response to the implants. In normotensive eyes, a 20% decrease in IOP obtained with the disks during 1 month was similar to Trusopt® eyedrops treatment. In hypertensive eyes, the most sustained decrease was shown by the high MW PCL (40% after 1 month, 30% after 2 months). It was shown that the implants can lower IOP in sustained manner in a rabbit glaucoma model.
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2011.05.047
Rights: openAccess
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais

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