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https://hdl.handle.net/10316/107496
Título: | Tryptanthrin and Its Derivatives in Drug Discovery: Synthetic Insights | Autor: | Brandão, Pedro Pineiro, Marta Burke, Anthony J. |
Palavras-chave: | tryptanthrin; indoloquinazoline derivatives; bioactive compounds; drug design | Data: | 2022 | Editora: | Thieme | Projeto: | FCT - PhD grant PD/BD/128490/2017 - CATSUS FCT-PhD Program (PD/00248/2012) UIDB/00313/2020 UIDP/00313/2020 UIDB/50006/2020 |
Título da revista, periódico, livro ou evento: | Synthesis | Volume: | 54 | Número: | 19 | Resumo: | Tryptanthrin is a golden-yellow, naturally occurring alkaloid that can be obtained from multiple sources and through different synthetic methodologies. This tetracyclic compound displays several relevant biological activities. The potential of this tetracyclic alkaloid has been widely explored, and several researchers have focused their attention on expanding the variety of tryptanthrin derivatives by using a range of synthetic strategies. In this short review, we aim to address recent developments in the synthesis of the tryptanthrin core, as well as the development of new strategies employed by synthetic organic chemists to obtain novel tryptanthrin derivatives with potential biological activity, using different tools from the chemists’ toolbox, such as photocatalysis, solvent-free approaches, and multicomponent reactions. | URI: | https://hdl.handle.net/10316/107496 | ISSN: | 0039-7881 1437-210X |
DOI: | 10.1055/s-0040-1719901 | Direitos: | openAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Brandao2022Synthesis.pdf | 6.52 MB | Adobe PDF | Ver/Abrir |
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