Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107496
Title: Tryptanthrin and Its Derivatives in Drug Discovery: Synthetic Insights
Authors: Brandão, Pedro 
Pineiro, Marta 
Burke, Anthony J. 
Keywords: tryptanthrin; indoloquinazoline derivatives; bioactive compounds; drug design
Issue Date: 2022
Publisher: Thieme
Project: FCT - PhD grant PD/BD/128490/2017 - CATSUS FCT-PhD Program (PD/00248/2012) 
UIDB/00313/2020 
UIDP/00313/2020 
UIDB/50006/2020 
Serial title, monograph or event: Synthesis
Volume: 54
Issue: 19
Abstract: Tryptanthrin is a golden-yellow, naturally occurring alkaloid that can be obtained from multiple sources and through different synthetic methodologies. This tetracyclic compound displays several relevant biological activities. The potential of this tetracyclic alkaloid has been widely explored, and several researchers have focused their attention on expanding the variety of tryptanthrin derivatives by using a range of synthetic strategies. In this short review, we aim to address recent developments in the synthesis of the tryptanthrin core, as well as the development of new strategies employed by synthetic organic chemists to obtain novel tryptanthrin derivatives with potential biological activity, using different tools from the chemists’ toolbox, such as photocatalysis, solvent-free approaches, and multicomponent reactions.
URI: https://hdl.handle.net/10316/107496
ISSN: 0039-7881
1437-210X
DOI: 10.1055/s-0040-1719901
Rights: openAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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