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https://hdl.handle.net/10316/107440
Title: | Engaging Isatins in Multicomponent Reactions (MCRs) - Easy Access to Structural Diversity | Authors: | Brandão, Pedro Marques, Carolina S. Carreiro, Elisabete P. Pineiro, Marta Burke, Anthony J. |
Keywords: | isatin; multicomponent reactions; spiroxindoles; bis-oxindoles; 3,3-disubstituted oxindoles; oxindole; sustainability; catalysis; nanocatalysts; diversity oriented synthesis | Issue Date: | Apr-2021 | Publisher: | Wiley Online Library | Project: | info:eu-repo/grantAgreement/FCT/POR_CENTRO/PD/BD/128490/2017/PT/Sustainable Asymmetric Catalytic Synthesis of Novel Oxindole Hybrids with Potential Biological Activity UIDB/50006/2020 UIDB/00313/2020 |
Serial title, monograph or event: | The Chemical Record | Volume: | 21 | Issue: | 4 | Abstract: | Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained. | URI: | https://hdl.handle.net/10316/107440 | ISSN: | 1527-8999 1528-0691 |
DOI: | 10.1002/tcr.202000167 | Rights: | embargoedAccess |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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Brandao2021ChemRec.pdf | 28.63 MB | Adobe PDF | View/Open |
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