Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107440
Title: Engaging Isatins in Multicomponent Reactions (MCRs) - Easy Access to Structural Diversity
Authors: Brandão, Pedro 
Marques, Carolina S.
Carreiro, Elisabete P. 
Pineiro, Marta 
Burke, Anthony J.
Keywords: isatin; multicomponent reactions; spiroxindoles; bis-oxindoles; 3,3-disubstituted oxindoles; oxindole; sustainability; catalysis; nanocatalysts; diversity oriented synthesis
Issue Date: Apr-2021
Publisher: Wiley Online Library
Project: info:eu-repo/grantAgreement/FCT/POR_CENTRO/PD/BD/128490/2017/PT/Sustainable Asymmetric Catalytic Synthesis of Novel Oxindole Hybrids with Potential Biological Activity 
info:eu-repo/grantAgreement/FCT/UIDB/00313/2020 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/50006/2020/PT/Associated Laboratory for Green Chemistry - Clean Technologies and Processes 
Serial title, monograph or event: The Chemical Record
Volume: 21
Issue: 4
Abstract: Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained.
URI: https://hdl.handle.net/10316/107440
ISSN: 1527-8999
1528-0691
DOI: 10.1002/tcr.202000167
Rights: embargoedAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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