Empadinhas, Nuno

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Credit Name
Empadinhas, Nuno
 
Name
Empadinhas, Nuno
 
Variants
Empadinhas, Nuno
 
Unidade de I&D
 
Email
nuno.empadinhas@uc.pt
 
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Ciência ID
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Nuno Empadinhas graduated in Biology and received a PhD in Biochemistry with specialty in Microbiology from the University of Coimbra (UC). He is Principal Investigator and Group Leader at the Center for Neuroscience and Cell Biology (CNC) at the UC. His research in Microbial Physiology has focused on deciphering molecular mechanisms of microbial adaptation to stress. He has studied microbes from extreme environments, mycobacterial pathogens and more recently the microbiota from the also extreme gut ecosystem. He has co-organized field research expeditions to isolate microbes from hotsprings and probed their biotechnological potential as producers of stabilizers of cells or proteins. In this context, he has elucidated biosynthetic pathways for compatible solutes in hyperthermophilic archaea, in thermophilic bacteria, and in desiccation/radiation resistant microbes. He has elucidated biosynthetic pathways for polymethylated lipid-transfer polysaccharides (PMPS) in Mycobacterium tuberculosis and in nontuberculous mycobacteria (NTM), many of which exceptionally resistant to stress agents including antibiotics, partly owing to an exceptional lipid-rich cell envelope and indirectly to PMPS. He secured funding to investigate the gut microbiome of Parkinson's patients and the biosynthesis of microbial neurotoxins, and also the diabetic skin and ulcers' microbiome, which led to an extensive culture collection of strains from these ecosystems. In his career as molecular microbiologist, he identified gene functions and enzyme activities that were the founding members of 14 new families at the IUBMB Nomenclature. He supervised or co-supervised 10 PhD and 12 Master students and 4 post-doctoral fellows, was invited speaker at >30 conferences, co-inventor in 2 international patents, published 3 book chapters and 59 papers, many of which in Top 10% Journals such as J Biol Chem, J Bacteriol, Mol Microbiol, Nat Prod Rep, mBio and PNAS. In 2021, he was awarded with the Mizutani Grant, the only time attributed to a scientist in Portugal since its foundation in 1993. In the last 10 years, he has coordinated and co-coordinated 10 projects with global funding >1.5 M euro by Fundação para a Ciência e a Tecnologia, Santa Casa da Misericórdia de Lisboa, Infarmed, Mizutani Foundation for Glycoscience (Japan), and participated in 15 other projects including 3 funded by the European Commission.
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Publications
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Date Issued:  [2020 TO 2023]

Results 1-12 of 12 (Search time: 0.017 seconds).

Issue DateTitleAuthor(s)TypeAccess
119-Nov-2021Biosynthesis of serotonin in bacteria: an exploratory studyGonçalves, Sara Miguel masterThesisopenAccess
22020Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immune SystemOriá, Reinaldo B; Empadinhas, Nuno ; Malva, João O. articleopenAccess
32022Enzyme Promiscuity in Serotonin Biosynthesis, From Bacteria to Plants and HumansGonçalves, Sara ; Nunes-Costa, Daniela; Cardoso, Sandra Morais ; Empadinhas, Nuno ; Marugg, John David articleopenAccess
426-Nov-2021Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondriaEsteves, A. Raquel ; Munoz-Pinto, Mário F.; Nunes-Costa, Daniela; Candeias, Emanuel ; Silva, Diana F. ; Magalhães, João D.; Pereira-Santos, A. Raquel ; Ferreira, I. Luisa; Alarico, Susana ; Tiago, Igor ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess
5Jan-2023Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondriaEsteves, A. Raquel ; Munoz-Pinto, Mário F; Nunes-Costa, Daniela ; Candeias, Emanuel ; Silva, Diana F. F. ; Magalhães, João Duarte ; Santos, A. Raquel Pereira ; Ferreira, Ildete L. ; Alarico, Susana ; Tiago, Igor ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess
626-Jul-2021Identificação de proteínas de micobactérias não tuberculosas envolvidas na agregação celular e formação de biofilmeFonseca, Ana Rita MarquesmasterThesisembargoedAccess
712-Mar-2021Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiotaMouritzen, Michelle V.; Petkovic, Marija ; Qvist, Katrine; Poulsen, Steen S.; Alarico, Susana ; Leal, Ermelindo C. ; Dalgaard, Louise T.; Empadinhas, Nuno ; Carvalho, Eugenia ; Jenssen, HåvardarticleopenAccess
82020Microbial BMAA and the Pathway for Parkinson's Disease NeurodegenerationNunes-Costa, Daniela ; Magalhães, João Duarte ; G-Fernandes, Maria ; Cardoso, Sandra Morais ; Empadinhas, Nuno articleopenAccess
95-Nov-2020Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer's disease features in cortical neuronsSilva, Diana F. ; Candeias, Emanuel ; Esteves, Ana Raquel Fernandes ; Magalhães, João Duarte ; Ferreira, I. Luísa ; Nunes-Costa, Daniela ; Rego, Ana Cristina ; Empadinhas, Nuno ; Cardoso, Sandra M. articleopenAccess
1027-Jan-2023Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharidesMaranha, Ana ; Costa, Mafalda ; Ripoll-Rozada, Jorge; Manso, José A.; Miranda, Vanessa; Mendes, Vera M. ; Manadas, Bruno ; Macedo-Ribeiro, Sandra ; Ventura, M. Rita; Pereira, Pedro José Barbosa; Empadinhas, Nuno articleopenAccess
112021The neuromicrobiology of Parkinson's disease: A unifying theoryMunoz-Pinto, Mario F.; Empadinhas, Nuno Miguel da Silva ; Cardoso, Sandra M. articleopenAccess
1222-Feb-2023The Role of Bacteria-Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson's DiseaseMagalhães, João Duarte ; Esteves, A. Raquel ; Candeias, Emanuel ; Silva, Diana F. F. ; Empadinhas, Nuno ; Cardoso, Sandra Morais articleopenAccess