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Credit Name
Ribeiro, Maria
Ribeiro, Maria J.
Ribeiro, M. J.
Scopus Author ID
Researcher ID
UC Researcher
One of the great mysteries is how the human brain creates and controls our thoughts, emotions and behaviour.
My research contributes towards unveiling the neural mechanisms behind perception, decision and action in humans using non-invasive neuroimaging techniques and physiological recordings.
Underneath is a summary of some of the projects in which I have been involved.

I am interested in understanding the neural changes that occur in ageing, are causal to cognitive decline and contribute for the onset of neurodegenerative diseases associated with the ageing process. In particular, I am studying the impact of changes in the ascending arousal systems of the brainstem. Neuromodulators with brainstem origin, like noradrenaline, dopamine and serotonin, can have a protective effect in the brain, keeping cognitive decline at bay. Yet, how these systems change with ageing and if we are able to modulate them to our benefit remains to be determined.
In previous studies, we have analysed the pupilogram and electrocardiogram (ECG) as indirect measures of activity in the arousal systems (Ribeiro and Castelo-Branco 2019a; Ribeiro and Castelo-Branco, 2019 b). These studies suggested reduced arousal modulation during perceptual decision-making in older people. In particular, task-related modulation of heart rate was reduced in older participants and correlated with reduced processing speed, suggesting that activity in these systems is directly associated with the cognitive abilities of older individuals.

In this study, we took advantage of the high temporal resolution of the electroencephalogram (EEG) to demonstrate that moment-to-moment fluctuations in the timing (and not amplitude) of neural responses in the visual cortex correlate with fluctuations in behavioural responses. Neuronal timing emerges as an important indicator of brain state fluctuations (Ribeiro et al., 2016).
We combined structural and functional magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) and electroencephalography (EEG) to elucidate the neural mechanisms behind the cognitive deficits observed in individuals with the monogenic disorder, neurofibromatosis type 1 (NF1).
Individuals with NF1 presented impaired cognitive control associated with deficient frontal activation and abnormal GABAergic transmission (Ribeiro et al., 2015; Violante et al., 2013). Brain structural differences were particularly pronounced in the white-matter. Using multivariate pattern analysis we were able to successfully classify patients from controls using brain imaging parameters (Duarte et al., 2014).
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Results 1-23 of 23 (Search time: 0.072 seconds).

Issue DateTitleAuthor(s)TypeAccess
12020A 2 Adenosine Receptors Mediate Whole-Body Insulin Sensitivity in a Prediabetes Animal Model: Primary Effects on Skeletal MuscleSacramento, Joana F.; Martins, Fátima O. ; Rodrigues, Tiago ; Matafome, Paulo N. ; Ribeiro, Maria J. ; Olea, Elena; Conde, Sílvia V. articleopenAccess
225-Jan-2012Abnormal achromatic and chromatic contrast sensitivity in neurofibromatosis type 1Ribeiro, Maria José ; Violante, Inês R ; Bernardino, Inês ; Ramos, Fabiana ; Saraiva, Jorge ; Reviriego, Pablo ; Upadhyaya, Meena ; Silva, Eduardo D. ; Castelo-Branco, Miguel articleopenAccess
32012Abnormal brain activation in neurofibromatosis type 1: a link between visual processing and the default mode networkViolante, Inês R. ; Ribeiro, Maria J. ; Cunha, Gil ; Bernardino, Inês ; Duarte, João V. ; Ramos, Fabiana ; Saraiva, Jorge ; Silva, Eduardo ; Castelo-Branco, Miguel articleopenAccess
421-Feb-2014Abnormal late visual responses and alpha oscillations in neurofibromatosis type 1: a link to visual and attention deficitsRibeiro, Maria J. ; Almeida, Otília C. d' ; Ramos, Fabiana ; Saraiva, Jorge ; Silva, Eduardo D. ; Castelo-Branco, Miguel articleopenAccess
5Mar-2015Abnormal relationship between GABA, neurophysiology and impulsive behavior in neurofibromatosis type 1Ribeiro, Maria J. ; Violante, Inês R ; Bernardino, Inês ; Edden, Richard A E ; Castelo-Branco, Miguel articleclosedAccess
6Feb-2015Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human LymphoblastsNaia, Luana ; Ferreira, I. Luísa ; Cunha-Oliveira, Teresa ; Duarte, Ana I. ; Ribeiro, Márcio ; Rosenstock, Tatiana R. ; Laço, Mário N. ; Ribeiro, Maria J. ; Oliveira, Catarina R. ; Saudou, Frédéric ; Humbert, Sandrine ; Rego, A. Cristina articleopenAccess
710-Nov-2020Age-related Changes in Arousal Modulation during Perceptual Decision-makingGomes, Catarina FerreiramasterThesisopenAccess
82008Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2Brás, José ; Guerreiro, Rita ; Ribeiro, Maria ; Morgadinho, Ana ; Januário, Cristina ; Dias, Margarida ; Calado, Ana ; Semedo, Cristina ; Oliveira, Catarina ; Hardy, John ; Singleton, Andrew articleopenAccess
928-Feb-2022Body-brain interactions in visual perceptionSousa, Nuno Geraldes demasterThesisopenAccess
1028-Sep-2017Computational model of the effect of alpha oscillatory phase on the timing of neuronal activations and resulting motor responsesVelez, Lea Cristele Rosa masterThesisopenAccess
11Mar-2016Computational modelling of brain statesVaz, Inês Isabel Geraldes masterThesisopenAccess
122010A disease model to understand neural mechanisms of visual perception: neurofibromatosis type-1Almeida, Otília da Anunciação Cardoso d' masterThesisopenAccess
131998FDG Accumulation and Tumor BiologyPauwels, E. K. J. ; Ribeiro, M. J. ; Stoot, J. H. M. B. ; McCready, V. R. ; Bourguignon, M. ; Mazière, B. articleopenAccess
1413-Feb-2013Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalitiesViolante, Inês R. ; Ribeiro, Maria J. ; Silva, Eduardo D. ; Castelo-Branco, Miguel articleopenAccess
1529-Sep-2017Motor excitability modulation during the delay period - a TMS and pupillometry studyVerdade, Andreia Martins de AlmeidamasterThesisopenAccess
162019A Novel Ecological Approach Reveals Early Executive Function Impairments in Huntington's DiseaseJúlio, Filipa ; Ribeiro, Maria J. ; Patrício, Miguel ; Malhão, Alexandre ; Pedrosa, Fábio ; Gonçalves, Hélio ; Simões, Marco ; van Asselen, Marieke ; Simões, Mário R. ; Castelo-Branco, Miguel ; Januário, Cristina articleopenAccess
172016Peripheral Attentional Targets under Covert Attention Lead to Paradoxically Enhanced Alpha Desynchronization in Neurofibromatosis Type 1Silva, Gilberto ; Ribeiro, Maria J. ; Costa, Gabriel N ; Violante, Inês ; Ramos, Fabiana ; Saraiva, Jorge ; Castelo-Branco, Miguel articleopenAccess
182014Predicting lapses in attention: a study of brain oscillations, neural synchrony and eye measuresPaiva, Joana Isabel Santos masterThesisopenAccess
1918-Jun-2010Psychophysical channels and ERP population responses in human visual cortex: area summation across chromatic and achromatic pathwaysRibeiro, Maria J. ; Castelo-Branco, Miguel articleclosedAccess
202-Oct-2015Role of interhemispherical connections in resting-state functional connectivityAlmeida, António Angelo Gouveia Rosa Perez de masterThesisopenAccess
2124-May-2022Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behaviorRibeiro, Maria ; Castelo-Branco, Miguel articleopenAccess
222016Spontaneous Fluctuations in Sensory Processing Predict Within-Subject Reaction Time VariabilityRibeiro, Maria J. ; Paiva, Joana S ; Castelo-Branco, Miguel articleopenAccess
2323-Sep-2016The role of long-range neural oscillatory synchrony as a mechanism underlying in perceptual coherenceDuarte, João Valente doctoralThesisopenAccess