Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/80833
Title: Gyrification, cortical and subcortical morphometry in neurofibromatosis type 1: an uneven profile of developmental abnormalities
Authors: Violante, Inês R 
Ribeiro, Maria J 
Silva, Eduardo D 
Castelo-Branco, Miguel 
Issue Date: 13-Feb-2013
Project: University of Coimbra grant number III/14/2008 
PIC/IC/82986/2007 
PIC/IC/ 83155/2007 
PTDC/SAU-ORG/118380 
SFRH/BD/41348/2007 
SFRH/BPD/34392/2006 
Serial title, monograph or event: Journal of Neurodevelopmental Disorders
Volume: 5
Issue: 1
Abstract: Neurofibromatosis type 1 (NF1) is a monogenic disorder associated with cognitive impairments. In order to understand how mutations in the NF1 gene impact brain structure it is essential to characterize in detail the brain structural abnormalities in patients with NF1. Previous studies have reported contradictory findings and have focused only on volumetric measurements. Here, we investigated the volumes of subcortical structures and the composite dimensions of the cortex through analysis of cortical volume, cortical thickness, cortical surface area and gyrification.
URI: http://hdl.handle.net/10316/80833
DOI: 10.1186/1866-1955-5-3
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais

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