Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/36255
Title: Role of interhemispherical connections in resting-state functional connectivity
Authors: Almeida, António Angelo Gouveia Rosa Perez de 
Orientador: Ribeiro, Maria José Braga
Keywords: Cérebro humano; Conexões interhemisféricas; Simulação da dinâmica neural
Issue Date: 2-Oct-2015
Serial title, monograph or event: Role of interhemispherical connections in resting-state functional connectivity
Place of publication or event: Coimbra
Abstract: The purpose of this thesis was to identify the role of interhemispherical connections in resting-state functional connectivity. Studying brain function in resting-state gives insight into patterns in anatomical connectivity and is increasingly important both as a proxy measure for structural connectivity and as a biomarker for brain changes in disease. We used the Kuramoto Model of Time Delays and Coupled Oscillators to evaluate the effect of reducing the strength of interhemispheric connections on the functional network of the brain, both with and without preserving the Anterior Commissure. Our findings indicate a monotonic reduction in interhemispheric functional connectivity as the strength of structural connections diminish, an increase of intrahemispheric connectivity as the strength of structural connections diminish below 40% of their original value and a unmistakable preservation of functional connectivity after total interhemispheric section when the anterior commissure is preserved, albeit with important quantitative changes in the network. These results present one more step in the way towards complete understanding of human brain.
Description: Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra
URI: http://hdl.handle.net/10316/36255
Rights: openAccess
Appears in Collections:UC - Dissertações de Mestrado
FCTUC Física - Teses de Mestrado

Files in This Item:
File Description SizeFormat
Role of interhemispherical connections in resting-state functional connectivity.pdf9.14 MBAdobe PDFView/Open
Show full item record

Page view(s)

283
checked on Oct 6, 2022

Download(s) 50

336
checked on Oct 6, 2022

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.