PTDC/BTM-SAL/29297/2017

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Primary Data

Project title
PTDC/BTM-SAL/29297/2017
Code
MitoScreening- Development and validation of innovative screening methods for mitochondrial health modulators
Organization
 
Start date
06-07-2018
Expected Completion
05-12-2021
 

Description

Abstract
The development of compounds with mitochondrial-targeted activity has a huge potential to overcome the cellular deficiencies present in different pathological situations. Mitochondrial dysfunction is involved in many human diseases and is a big player in the adverse effects of chemicals, and thus the characterization of mitochondrial dysfunction is important for adequate diagnostics and treatment of several human health conditions. Mitochondrial-targeted therapies are being developed to treat different types of diseases, although NO VALIDATED METHODS HAVE BEEN PUBLISHED for the systematic screening and characterization of mitochondria-directed compounds. In this project, we will develop innovative in vitro laboratorial and computational screening methods to assess mitochondrial health, using state-of-the-art equipment available at the UC Biotech (CNC) for high-throughput and high-content analysis of mitochondrial health biomarkers, bioenergetics, mtDNA copy number and mitochondria-related gene expression. Analysis of multidimensional data profiles generated will be performed by computational analysis at CISUC (UC).
 

Publications
(All)

Results 1-6 of 6 (Search time: 0.004 seconds).

Issue DateTitleAuthor(s)TypeAccess
12021Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 CardiomyoblastsMoukette, Bruno ; Castelão-Baptista, José P. ; Ferreira, Luciana L. ; Silva, Ana M. ; Simões, Rui F. ; Cabral, Célia ; Pieme, Constant A.; Ngogang, Jeanne Y.; Sardão, Vilma A. ; Oliveira, Paulo J. articleopenAccess
2Mar-2024Best practices for data management and sharing in experimental biomedical researchCunha-Oliveira, Teresa ; Ioannidis, John P. A.; Oliveira, Paulo J.articleembargoedAccess
319-May-2021Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 CellsAmorim, Ricardo ; Simões, Inês C. M.; Veloso, Caroline ; Carvalho, Adriana ; Simões, Rui F. ; Pereira, Francisco B. ; Thiel, Theresa; Normann, Andrea; Morais, Catarina M. ; Jurado, Maria Amália da Silva ; Wieckowski, Mariusz R. ; Teixeira, José ; Oliveira, Paulo J. articleopenAccess
410-May-2023Metabolic Priming as a Tool in Redox and Mitochondrial TheragnosticsPinho, Sónia A. ; Anjo, Sandra I. ; Cunha-Oliveira, Teresa articleopenAccess
52020Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological InterventionCunha-Oliveira, Teresa ; Montezinho, Liliana ; Mendes, Catarina; Firuzi, Omidreza; Saso, Luciano; Oliveira, Paulo J. ; Silva, Filomena S. G. articleopenAccess
628-Feb-2020Urine-Derived Stem Cells: Applications in Regenerative and Predictive MedicineBento, Guida ; Shafigullina, Aygul K.; Rizvanov, Albert A. ; Sardão, Vilma A. ; Macedo, Maria Paula ; Oliveira, Paulo J. articleopenAccess