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|Title:||Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine||Authors:||Bento, Guida
Shafigullina, Aygul K.
Rizvanov, Albert A.
Sardão, Vilma A.
Macedo, Maria Paula
Oliveira, Paulo J.
|Keywords:||urine-derived stem cells; personalized medicine; regenerative medicine; induced-pluripotent stem cells||Issue Date:||28-Feb-2020||Publisher:||MDPI||Project:||PTDC/BTM-SAL/29297/2017
Ph.D. fellowship PD/BD/114119/2015
subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities
Kazan Federal University was supported by the Russian Government Program of Competitive Growth
|Serial title, monograph or event:||Cells||Volume:||9||Issue:||3||Abstract:||Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC.||URI:||https://hdl.handle.net/10316/105857||ISSN:||2073-4409||DOI:||10.3390/cells9030573||Rights:||openAccess|
|Appears in Collections:||I&D CNC - Artigos em Revistas Internacionais|
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