Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105857
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bento, Guida | - |
dc.contributor.author | Shafigullina, Aygul K. | - |
dc.contributor.author | Rizvanov, Albert A. | - |
dc.contributor.author | Sardão, Vilma A. | - |
dc.contributor.author | Macedo, Maria Paula | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.date.accessioned | 2023-03-13T09:51:51Z | - |
dc.date.available | 2023-03-13T09:51:51Z | - |
dc.date.issued | 2020-02-28 | - |
dc.identifier.issn | 2073-4409 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105857 | - |
dc.description.abstract | Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | PTDC/BTM-SAL/29297/2017 | pt |
dc.relation | POCI-01-0145-FEDER-029297 | pt |
dc.relation | PTDC/MED-FAR/29391/2017 | pt |
dc.relation | POCI-01-0145-FEDER-029391 | pt |
dc.relation | IF/01182/2015 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | iNOVA4Health-UID/Multi/04462/2013 | pt |
dc.relation | Ph.D. fellowship PD/BD/114119/2015 | pt |
dc.relation | subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities | pt |
dc.relation | Kazan Federal University was supported by the Russian Government Program of Competitive Growth | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | urine-derived stem cells | pt |
dc.subject | personalized medicine | pt |
dc.subject | regenerative medicine | pt |
dc.subject | induced-pluripotent stem cells | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Drug Discovery | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Stem Cells | pt |
dc.subject.mesh | Urine | pt |
dc.subject.mesh | Precision Medicine | pt |
dc.subject.mesh | Regenerative Medicine | pt |
dc.title | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine | pt |
dc.type | article | - |
degois.publication.firstPage | 573 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | Cells | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/cells9030573 | pt |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2020-02-28 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7714-4833 | - |
crisitem.author.orcid | 0000-0001-7014-4614 | - |
crisitem.author.orcid | 0000-0002-2549-0275 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
UrineDerived-Stem-Cells-Applications-in-Regenerative-and-Predictive-MedicineCells.pdf | 1.25 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
36
checked on Apr 29, 2024
WEB OF SCIENCETM
Citations
39
checked on May 2, 2024
Page view(s)
54
checked on Apr 30, 2024
Download(s)
18
checked on Apr 30, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License