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|Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics
|Pinho, Sónia A.
Anjo, Sandra I.
|metabolic priming; theragnostics; mitochondria; redox homeostasis; media composition; oxygen levels
|This work was funded by the European Regional Development Fund (ERDF) through the Centro 2020 Regional Operational Programme under project CENTRO-01-0246-FEDER-000010 (Multidisciplinary Institute of Ageing in Coimbra); the COMPETE 2020–Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia under projects PTDC/BTM-SAL/29297/2017 and POCI-01-0145-FEDER- 029297; EXPL/BTM-TEC/1407/2021, UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020. S.A.P., S.I.A., and T.C.-O. were supported by the PhD fellowship SFRH/PD/BD/143055/2018, CEEC grant 2021.04378.CEECIND, and DL57/2016/CP1448/CT0016, respectively, cofinanced by the European Social Fund (ESF) through the POCH—Programa Operacional do Capital Humano and national funds via FCT.
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|Theragnostics is a promising approach that integrates diagnostics and therapeutics into a single personalized strategy. To conduct effective theragnostic studies, it is essential to create an in vitro environment that accurately reflects the in vivo conditions. In this review, we discuss the importance of redox homeostasis and mitochondrial function in the context of personalized theragnostic approaches. Cells have several ways to respond to metabolic stress, including changes in protein localization, density, and degradation, which can promote cell survival. However, disruption of redox homeostasis can lead to oxidative stress and cellular damage, which are implicated in various diseases. Models of oxidative stress and mitochondrial dysfunction should be developed in metabolically conditioned cells to explore the underlying mechanisms of diseases and develop new therapies. By choosing an appropriate cellular model, adjusting cell culture conditions and validating the cellular model, it is possible to identify the most promising therapeutic options and tailor treatments to individual patients. Overall, we highlight the importance of precise and individualized approaches in theragnostics and the need to develop accurate in vitro models that reflect the in vivo conditions.
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|I&D CIBB - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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