Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/80903
Título: | Aging Hallmarks: The Benefits of Physical Exercise | Autor: | Rebelo-Marques, Alexandre Lages, Adriana De Sousa Andrade, Renato Ribeiro, Carlos Fontes Mota-Pinto, Anabela Carrilho, Francisco Espregueira-Mendes, João |
Palavras-chave: | Aging/Envelhecimento; Exercício Físico/Physical Exercise | Data: | 2018 | Editora: | Frontiers | Título da revista, periódico, livro ou evento: | Frontiers in Endocrinology | Volume: | 9 | Resumo: | World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged. | URI: | https://hdl.handle.net/10316/80903 | DOI: | 10.3389/fendo.2018.00258 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Aging_Hallmarks_The_Benefits_of_Physical_Exercise.pdf | 563.94 kB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
155
Visto em 7/out/2024
Citações WEB OF SCIENCETM
5
146
Visto em 2/out/2024
Visualizações de página 50
563
Visto em 8/out/2024
Downloads 50
739
Visto em 8/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.