Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/80903
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rebelo-Marques, Alexandre | - |
dc.contributor.author | Lages, Adriana De Sousa | - |
dc.contributor.author | Andrade, Renato | - |
dc.contributor.author | Ribeiro, Carlos Fontes | - |
dc.contributor.author | Mota-Pinto, Anabela | - |
dc.contributor.author | Carrilho, Francisco | - |
dc.contributor.author | Espregueira-Mendes, João | - |
dc.date.accessioned | 2018-09-25T13:18:44Z | - |
dc.date.available | 2018-09-25T13:18:44Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://hdl.handle.net/10316/80903 | - |
dc.description.abstract | World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers | pt |
dc.rights | openAccess | pt |
dc.subject | Aging/Envelhecimento | pt |
dc.subject | Exercício Físico/Physical Exercise | pt |
dc.title | Aging Hallmarks: The Benefits of Physical Exercise | pt |
dc.type | article | - |
degois.publication.firstPage | 258 | pt |
degois.publication.title | Frontiers in Endocrinology | pt |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fendo.2018.00258/full | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fendo.2018.00258 | pt |
degois.publication.volume | 9 | pt |
dc.date.embargo | 2018-01-01 | * |
dc.date.periodoembargo | 0 | pt |
dc.identifier.pmid | 29887832 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-7739-8887 | - |
crisitem.author.orcid | 0000-0002-9707-4895 | - |
crisitem.author.orcid | 0000-0002-0820-9568 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Aging_Hallmarks_The_Benefits_of_Physical_Exercise.pdf | 563.94 kB | Adobe PDF | View/Open |
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