Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/80179
Title: Poly(ester amide)s based on (L)-lactic acid oligomers and α-amino acids: influence of the α-amino acid side chain in the poly(ester amide)s properties
Authors: Fonseca, Ana C 
Coelho, Jorge F J 
Valente, Joana F A 
Correia, Tiago R 
Correia, Ilídio J 
Gil, Maria H 
Simões, Pedro N 
Issue Date: 2013
Abstract: Novel biodegradable and low cytotoxic poly(ester amide)s (PEAs) based on α-amino acids and (L)-lactic acid (L-LA) oligomers were successfully synthesized by interfacial polymerization. The chemical structure of the new polymers was confirmed by spectroscopic analyses. Further characterization suggests that the α-amino acid plays a critical role on the final properties of the PEA. L-phenylalanine provides PEAs with higher glass transition temperature, whereas glycine enhances the crystallinity. The hydrolytic degradation in PBS (pH = 7.4) at 37 °C also depends on the α-amino acid, being faster for glycine-based PEAs. The cytotoxic profiles using fibroblast human cells indicate that the PEAs did not elicit an acute cytotoxic effect. The strategy presented in this work opens the possibility of synthesizing biodegradable PEAs with low citotoxicity by an easy and fast method. It is worth to mention also that the properties of these materials can be fine-tuned only by changing the α-amino acid.
URI: http://hdl.handle.net/10316/80179
DOI: 10.1080/09205063.2012.762293
Rights: openAccess
Appears in Collections:I&D CIEPQPF - Artigos em Revistas Internacionais

Show full item record

SCOPUSTM   
Citations

9
checked on Jun 25, 2019

WEB OF SCIENCETM
Citations

7
checked on Jun 25, 2019

Page view(s)

82
checked on Oct 2, 2019

Download(s)

95
checked on Oct 2, 2019

Google ScholarTM

Check

Altmetric

Dimensions


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.