Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/80147
Title: | Synthesis of a dextran based thermo-sensitive drug delivery system by gamma irradiation | Authors: | Almeida, J. F. Ferreira, P. Alves, P. Lopes, A. Gil, M. H. |
Issue Date: | Oct-2013 | Abstract: | Gamma radiation was used as the initiator/crosslinker agent for the synthesis of thermo-sensitive hydrogel networks, under the form of membranes, using dextran and N-isopropylacrylamide. The prepared membranes were loaded with Ondansetron™, a potent antiemetic drug and tested as drug delivery systems. The characterization of the materials was accomplished by: Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, elemental analysis, lower critical solution temperature (LCST) determination, swelling behaviour evaluation, determination of surface energy by contact angle measurement and drug delivery kinetics studies. Also, the influence of irradiation time and temperature on the materials properties was evaluated. | URI: | https://hdl.handle.net/10316/80147 | DOI: | 10.1016/j.ijbiomac.2013.07.002 | Rights: | openAccess |
Appears in Collections: | I&D CERES - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0141813013003851-main.pdf | 837.58 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
18
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
10
17
checked on Oct 2, 2024
Page view(s)
345
checked on Oct 15, 2024
Download(s)
382
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.