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https://hdl.handle.net/10316/5349
Title: | Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis | Authors: | Teodoro, João Rolo, Anabela P. Oliveira, Paulo J. Palmeira, Carlos M. |
Keywords: | Non-alcoholic fatty liver; Mitochondrion; Oxidative phosphorylation | Issue Date: | 2006 | Citation: | FEBS Letters. 580:8 (2006) 2153-2157 | Abstract: | Mitochondria from Zucker fatty (ZF) rats (a model for fatty liver disease) showed a delay in the repolarization after a phosphorylative cycle and a decrease on state 3 respiration, suggesting alterations at the phosphorylative system level. The ATPase activity showed no differences between control and ZF rats, implying alterations in other components of the phosphorylative system. A pronounced depletion in the content of the adenine nucleotide translocator (ANT) was observed by Western blotting, while no alterations were found in the mitochondrial voltage-dependent anion channel content. These data suggest that hepatic accumulation of fat impairs mitochondrial function, reflecting the loss of oxidative phosphorylation capacity caused by a decrease in the ANT content. | URI: | https://hdl.handle.net/10316/5349 | DOI: | 10.1016/j.febslet.2006.02.078 | Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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