Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/5349
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Teodoro, João | - |
dc.contributor.author | Rolo, Anabela P. | - |
dc.contributor.author | Oliveira, Paulo J. | - |
dc.contributor.author | Palmeira, Carlos M. | - |
dc.date.accessioned | 2008-09-01T15:40:44Z | - |
dc.date.available | 2008-09-01T15:40:44Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | FEBS Letters. 580:8 (2006) 2153-2157 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5349 | - |
dc.description.abstract | Mitochondria from Zucker fatty (ZF) rats (a model for fatty liver disease) showed a delay in the repolarization after a phosphorylative cycle and a decrease on state 3 respiration, suggesting alterations at the phosphorylative system level. The ATPase activity showed no differences between control and ZF rats, implying alterations in other components of the phosphorylative system. A pronounced depletion in the content of the adenine nucleotide translocator (ANT) was observed by Western blotting, while no alterations were found in the mitochondrial voltage-dependent anion channel content. These data suggest that hepatic accumulation of fat impairs mitochondrial function, reflecting the loss of oxidative phosphorylation capacity caused by a decrease in the ANT content. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6T36-4JDVM3N-3/1/6ab136a93292166e1e8c351ee22e4cdb | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Non-alcoholic fatty liver | en_US |
dc.subject | Mitochondrion | en_US |
dc.subject | Oxidative phosphorylation | en_US |
dc.title | Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.febslet.2006.02.078 | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-1244-275X | - |
crisitem.author.orcid | 0000-0003-3535-9630 | - |
crisitem.author.orcid | 0000-0002-5201-9948 | - |
crisitem.author.orcid | 0000-0002-2639-7697 | - |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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file79c288b71c7c45b79ba210f9b5421280.pdf | 426.6 kB | Adobe PDF | Ver/Abrir |
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