Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5160
Title: | Detection of the damage caused to DNA by a thiophene-S-oxide using an electrochemical DNA-biosensor | Authors: | Brett, Ana Maria Oliveira Silva, Luis Antônio da Fujii, Hideki Mataka, Shuntaro Thiemann, Thies |
Keywords: | Thiophene-S-oxide; DNA-biosensor; Oxidative damage; 8-Oxoguanine; Voltammetry; Electrochemistry; Oxidation; Reduction; DNA-electrochemical biosensors | Issue Date: | 2003 | Citation: | Journal of Electroanalytical Chemistry. 549:(2003) 91-99 | Abstract: | The electrochemistry of 3,4-dibenzyl-2,5-dimethylthiophene-S-oxide was investigated as well as its interaction with dsDNA. The electrochemical study of the thiophene-S-oxide was performed at different pH values, in a mixed solvent and by solid state voltammetry, and showed that the molecule is reduced at a very negative potential, and the reduction is pH dependent. A glassy carbon electrode modified with a thick thiophene-S-oxide+dsDNA mixture was used to study the interaction of thiophene-S-oxide in situ with dsDNA at a charged interface. The experimental results give strong evidence that the reduced thiophene-S-oxide interacts with dsDNA causing damage with possible strand break and that the thiophene-S-oxide adduct formed with dsDNA can still undergo reduction. | URI: | https://hdl.handle.net/10316/5160 | DOI: | 10.1016/S0022-0728(03)00245-6 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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file61fcb5c87a5a46079095a5b7676e4f8d.pdf | 649.9 kB | Adobe PDF | View/Open |
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