Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/5160
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dc.contributor.authorBrett, Ana Maria Oliveira-
dc.contributor.authorSilva, Luis Antônio da-
dc.contributor.authorFujii, Hideki-
dc.contributor.authorMataka, Shuntaro-
dc.contributor.authorThiemann, Thies-
dc.date.accessioned2008-09-01T15:04:59Z-
dc.date.available2008-09-01T15:04:59Z-
dc.date.issued2003en_US
dc.identifier.citationJournal of Electroanalytical Chemistry. 549:(2003) 91-99en_US
dc.identifier.urihttps://hdl.handle.net/10316/5160-
dc.description.abstractThe electrochemistry of 3,4-dibenzyl-2,5-dimethylthiophene-S-oxide was investigated as well as its interaction with dsDNA. The electrochemical study of the thiophene-S-oxide was performed at different pH values, in a mixed solvent and by solid state voltammetry, and showed that the molecule is reduced at a very negative potential, and the reduction is pH dependent. A glassy carbon electrode modified with a thick thiophene-S-oxide+dsDNA mixture was used to study the interaction of thiophene-S-oxide in situ with dsDNA at a charged interface. The experimental results give strong evidence that the reduced thiophene-S-oxide interacts with dsDNA causing damage with possible strand break and that the thiophene-S-oxide adduct formed with dsDNA can still undergo reduction.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6TGB-48R1X8W-4/1/27fc80a2560eca0f5280d7b80cebe4a6en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectThiophene-S-oxideen_US
dc.subjectDNA-biosensoren_US
dc.subjectOxidative damageen_US
dc.subject8-Oxoguanineen_US
dc.subjectVoltammetryen_US
dc.subjectElectrochemistryen_US
dc.subjectOxidationen_US
dc.subjectReductionen_US
dc.subjectDNA-electrochemical biosensorsen_US
dc.titleDetection of the damage caused to DNA by a thiophene-S-oxide using an electrochemical DNA-biosensoren_US
dc.typearticleen_US
dc.identifier.doi10.1016/S0022-0728(03)00245-6-
item.fulltextCom Texto completo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypearticle-
item.cerifentitytypePublications-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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