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https://hdl.handle.net/10316/5012
Título: | Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients | Autor: | Monteiro, Carlos J. P. Pereira, Mariette M. Pinto, Sara M. A. Simões, Ana V. C. Sá, Gonçalo F. F. Arnaut, Luís G. Formosinho, Sebastião J. Simões, Sérgio Wyatt, Mark F. |
Palavras-chave: | Amphiphilic porphyrins synthesis; 1-Octanol/water partition coefficients; MALDI-TOFMS | Data: | 2008 | Citação: | Tetrahedron. 64:22 (2008) 5132-5138 | Resumo: | Porphyrins are key precursors for development of photosensitizers for photodynamic therapy. A new series of ortho-halogenated tetraarylporphyrins with sulfonamide substituents have been synthesized via chlorosulfonation reaction and characterized by MALDI-TOFMS. To predict their partition properties, log KOW of a selected range of the synthesized halogenated amphiphilic porphyrins is described. A significant effect of the number and type of halogen group as well as on the number of sulfonamide side chain was observed. The determined 1-octanol/water partition coefficients showed that it is possible to obtain compounds with a wide range of lipophilicities, from log KOW=-2.71 till log KOW>4, which are suitable to optimize the biological efficacy of this class of sensitizers. | URI: | https://hdl.handle.net/10316/5012 | DOI: | 10.1016/j.tet.2008.03.055 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
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file90d8ca95032a4d89b0b5751fa467f4d2.pdf | 326.31 kB | Adobe PDF | Ver/Abrir |
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