Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/5012
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dc.contributor.authorMonteiro, Carlos J. P.-
dc.contributor.authorPereira, Mariette M.-
dc.contributor.authorPinto, Sara M. A.-
dc.contributor.authorSimões, Ana V. C.-
dc.contributor.authorSá, Gonçalo F. F.-
dc.contributor.authorArnaut, Luís G.-
dc.contributor.authorFormosinho, Sebastião J.-
dc.contributor.authorSimões, Sérgio-
dc.contributor.authorWyatt, Mark F.-
dc.date.accessioned2008-09-01T15:02:25Z-
dc.date.available2008-09-01T15:02:25Z-
dc.date.issued2008en_US
dc.identifier.citationTetrahedron. 64:22 (2008) 5132-5138en_US
dc.identifier.urihttps://hdl.handle.net/10316/5012-
dc.description.abstractPorphyrins are key precursors for development of photosensitizers for photodynamic therapy. A new series of ortho-halogenated tetraarylporphyrins with sulfonamide substituents have been synthesized via chlorosulfonation reaction and characterized by MALDI-TOFMS. To predict their partition properties, log KOW of a selected range of the synthesized halogenated amphiphilic porphyrins is described. A significant effect of the number and type of halogen group as well as on the number of sulfonamide side chain was observed. The determined 1-octanol/water partition coefficients showed that it is possible to obtain compounds with a wide range of lipophilicities, from log KOW=-2.71 till log KOW>4, which are suitable to optimize the biological efficacy of this class of sensitizers.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6THR-4S3S2CR-3/1/354752ab2cc5e753ede41d0a4595c5a6en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAmphiphilic porphyrins synthesisen_US
dc.subject1-Octanol/water partition coefficientsen_US
dc.subjectMALDI-TOFMSen_US
dc.titleSynthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficientsen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.tet.2008.03.055-
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0003-4958-7677-
crisitem.author.orcid0000-0003-3817-1182-
crisitem.author.orcid0000-0002-3223-4819-
crisitem.author.orcid0000-0001-6607-0026-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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