Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5012
DC Field | Value | Language |
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dc.contributor.author | Monteiro, Carlos J. P. | - |
dc.contributor.author | Pereira, Mariette M. | - |
dc.contributor.author | Pinto, Sara M. A. | - |
dc.contributor.author | Simões, Ana V. C. | - |
dc.contributor.author | Sá, Gonçalo F. F. | - |
dc.contributor.author | Arnaut, Luís G. | - |
dc.contributor.author | Formosinho, Sebastião J. | - |
dc.contributor.author | Simões, Sérgio | - |
dc.contributor.author | Wyatt, Mark F. | - |
dc.date.accessioned | 2008-09-01T15:02:25Z | - |
dc.date.available | 2008-09-01T15:02:25Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Tetrahedron. 64:22 (2008) 5132-5138 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5012 | - |
dc.description.abstract | Porphyrins are key precursors for development of photosensitizers for photodynamic therapy. A new series of ortho-halogenated tetraarylporphyrins with sulfonamide substituents have been synthesized via chlorosulfonation reaction and characterized by MALDI-TOFMS. To predict their partition properties, log KOW of a selected range of the synthesized halogenated amphiphilic porphyrins is described. A significant effect of the number and type of halogen group as well as on the number of sulfonamide side chain was observed. The determined 1-octanol/water partition coefficients showed that it is possible to obtain compounds with a wide range of lipophilicities, from log KOW=-2.71 till log KOW>4, which are suitable to optimize the biological efficacy of this class of sensitizers. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6THR-4S3S2CR-3/1/354752ab2cc5e753ede41d0a4595c5a6 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Amphiphilic porphyrins synthesis | en_US |
dc.subject | 1-Octanol/water partition coefficients | en_US |
dc.subject | MALDI-TOFMS | en_US |
dc.title | Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.tet.2008.03.055 | - |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-4958-7677 | - |
crisitem.author.orcid | 0000-0003-3817-1182 | - |
crisitem.author.orcid | 0000-0002-3223-4819 | - |
crisitem.author.orcid | 0000-0001-6607-0026 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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file90d8ca95032a4d89b0b5751fa467f4d2.pdf | 326.31 kB | Adobe PDF | View/Open |
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