Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/48362
Title: Membrane proteins structures: A review on computational modeling tools
Authors: Almeida, Jose G. 
Preto, Antonio J. 
Koukos, Panagiotis I. 
Bonvin, Alexandre M.J.J. 
Moreira, Irina S. 
Keywords: Algorithms; Computational Biology; Humans; Membrane Proteins; Molecular Dynamics Simulation; Software
Issue Date: 15-Jul-2017
Project: F/00578/2014 
MEMBRANEPROT 659826 
CENTRO-01-0145-FEDER-000008 
TOP-PUNT grant BC.000664.1 
Abstract: Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights.
URI: http://hdl.handle.net/10316/48362
DOI: 10.1016/j.bbamem.2017.07.008
Rights: embargoedAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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