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https://hdl.handle.net/10316/45374
Title: | Iontophoretic transdermal drug delivery: a multi-layered approach | Authors: | Pontrelli, Giuseppe Lauricella, Marco Ferreira, José Augusto Pena, Gonçalo |
Issue Date: | 2017 | Publisher: | Oxford University Press | Project: | info:eu-repo/grantAgreement/FCT/5876/147205/PT | Serial title, monograph or event: | Mathematical Medicine and Biology | Volume: | 34 | Issue: | 4 | Abstract: | We present a multi-layer mathematical model to describe the the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describe the basic convection-diffusion process, with the electric potential obtained by Laplace equation. These equations are complemented with suitable interface and boundary conditions in a multi-domain. The stability of the mathematical problem is discussed in different scenarios and a finite-difference method is used to solve the coupled system. Numerical experiments are included to illustrate the drug dynamics under different conditions. | URI: | https://hdl.handle.net/10316/45374 | DOI: | 10.1093/imammb/dqw017 | Rights: | embargoedAccess |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
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paper3.pdf | 4.54 MB | Adobe PDF | View/Open |
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