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Title: Iontophoretic transdermal drug delivery: a multi-layered approach
Authors: Pontrelli, Giuseppe 
Lauricella, Marco 
Ferreira, José Augusto 
Pena, Gonçalo 
Issue Date: 2017
Publisher: Oxford University Press
Project: info:eu-repo/grantAgreement/FCT/5876/147205/PT 
Serial title, monograph or event: Mathematical Medicine and Biology
Volume: 34
Issue: 4
Abstract: We present a multi-layer mathematical model to describe the the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describe the basic convection-diffusion process, with the electric potential obtained by Laplace equation. These equations are complemented with suitable interface and boundary conditions in a multi-domain. The stability of the mathematical problem is discussed in different scenarios and a finite-difference method is used to solve the coupled system. Numerical experiments are included to illustrate the drug dynamics under different conditions.
Other Identifiers: 10.1093/imammb/dqw017
Rights: embargoedAccess
Appears in Collections:I&D CMUC - Artigos em Revistas Internacionais

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