Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/45269
Title: | Numerical and analytical study of drug release from a biodegradable viscoelastic platform | Authors: | Azhdari, Ebrahim Ferreira, José Augusto Oliveira, Paula de Silva, Pascoal |
Issue Date: | 2016 | Publisher: | Wiley | Project: | info:eu-repo/grantAgreement/FCT/COMPETE/132981/PT | Serial title, monograph or event: | Mathematical Methods in the Applied Sciences | Volume: | 39 | Issue: | 16 | Abstract: | A mathematical model to simulate drug delivery from a viscoelastic erodible matrix is presented in this paper. The drug is initially distributed in the matrix that is in contact with water. The entrance of water in the material changes the molecular weight, and bulk erosion can be developed depending on how fast this entrance is and how fast degradation occurs. The viscoelastic properties of the matrix also change in the presence of water as the molecular weight changes. The model is represented by a system of quasi-linear partial differential equations that take into account different phenomena: the uptake of water, the decreasing of the molecular weight, the viscoelastic behavior, the dissolution of the solid drug, and the delivery of the dissolved drug. Numerical simulations illustrating the behavior of the model are included. | URI: | https://hdl.handle.net/10316/45269 | DOI: | 10.1002/mma.3375 10.1002/mma.3375 |
Rights: | embargoedAccess |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Artigo.pdf | 5.53 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
10
9
checked on Oct 2, 2024
Page view(s)
311
checked on Oct 15, 2024
Download(s)
279
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.