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https://hdl.handle.net/10316/3836
Title: | Preparation and characterisation of gels based on sucrose modified with glycidyl methacrylate | Authors: | Ferreira, L. Vidal, M. M. Geraldes, C. F. G. C. Gil, M. H. |
Keywords: | Sucrose; Glycidyl methacrylate; Swelling; Drug release | Issue Date: | 2000 | Citation: | Carbohydrate Polymers. 41:1 (2000) 15-24 | Abstract: | Sugar-based hydrogels were prepared by non-selective modification of sucrose with the introduction of vinyl groups. Sucrose was reacted with glycidyl methacrylate (1:1 molar ratio) in DMSO and in the presence of 4-(N,N-dimethylamino)pyridine (4-DMAP) as catalyst. The structure of the product (SucMA) was established using 1H NMR, 1H DQF-COSY NMR and 13C NMR analysis. Gels were prepared by copolymerisation of hydroxyethyl methacrylate (HEMA) and SucMA in a 70:30 ethylene glycol/water mixed solvent using ammonium persulphate/sodium methabisulphite pair as initiating system. The swelling behaviour of these gels was evaluated as a function of crosslinker content, copolymer composition, pH and ionic strength. In addition, the diffusional behaviour of sodium salycilate (SSA) from these gels and poly(HEMA) gels is also reported. | URI: | https://hdl.handle.net/10316/3836 | DOI: | 10.1016/s0144-8617(97)87382-1 | Rights: | openAccess |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais |
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file198c5680c3be4613a8eb5025abb3f5e9.pdf | 212.05 kB | Adobe PDF | View/Open |
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