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Title: Multimodal Imaging Probes for the Diagnostics of Alzheimer’s Disease
Authors: Martins, Andre Ferreira 
Orientador: Geraldes, Carlos
Toth, Eva Jakab
Keywords: Alzheimer; MRI
Issue Date: 12-Jun-2013
Citation: MARTINS, André Ferreira - Multimodal imaging probes for the diagnostics of Alzheimer’s Disease. Coimbra : [s.n.], 2013. Tese de doutoramento. Disponível na WWW:
Abstract: Alzheimer’s disease (AD) is the most frequent form of intellectual deterioration in elderly individuals, characterized by the brain deposition of amyloid plaques and neurofibrillary tangles. Early detection of the β-amyloid (Aβ) deposits in vivo is very difficult. Recently 11C-radiolabeled small-molecules have been developed, capable of entering the brain and specifically targeting amyloid plaques for imaging with PET, such as several Thioflavin T derivatives. In particular, the uncharged analogue 6-OH-BTA-1 (Pittsburgh compound B- PiB) is highly efficient both in crossing the BBB and in selective binding to AD amyloid aggregates. The use of Aβ marker linked to a MRI CA would constitute an attractive noninvasive in vivo imaging approach.
Description: Tese de doutoramento em Bioquímica, na especialidade de Biofísica Molecular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra
Rights: embargoedAccess
Appears in Collections:FCTUC Ciências da Vida - Teses de Doutoramento

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