Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/23523
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Geraldes, Carlos | - |
dc.contributor.advisor | Toth, Eva Jakab | - |
dc.contributor.author | Martins, Andre Ferreira | - |
dc.date.accessioned | 2013-06-12T20:10:25Z | - |
dc.date.available | 2014-05-11T02:00:45Z | - |
dc.date.issued | 2013-06-12 | - |
dc.date.submitted | 2013-11-11 | - |
dc.identifier.citation | MARTINS, André Ferreira - Multimodal imaging probes for the diagnostics of Alzheimer’s Disease. Coimbra : [s.n.], 2013. Tese de doutoramento. Disponível na WWW: http://hdl.handle.net/10316/23523 | - |
dc.identifier.uri | https://hdl.handle.net/10316/23523 | - |
dc.description | Tese de doutoramento em Bioquímica, na especialidade de Biofísica Molecular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra | - |
dc.description.abstract | Alzheimer’s disease (AD) is the most frequent form of intellectual deterioration in elderly individuals, characterized by the brain deposition of amyloid plaques and neurofibrillary tangles. Early detection of the β-amyloid (Aβ) deposits in vivo is very difficult. Recently 11C-radiolabeled small-molecules have been developed, capable of entering the brain and specifically targeting amyloid plaques for imaging with PET, such as several Thioflavin T derivatives. In particular, the uncharged analogue 6-OH-BTA-1 (Pittsburgh compound B- PiB) is highly efficient both in crossing the BBB and in selective binding to AD amyloid aggregates. The use of Aβ marker linked to a MRI CA would constitute an attractive noninvasive in vivo imaging approach. | por |
dc.description.sponsorship | FCT - SFRH/BD/46370/2008 e CNRS - Orléans | - |
dc.language.iso | eng | por |
dc.rights | embargoedAccess | por |
dc.subject | Alzheimer | por |
dc.subject | MRI | por |
dc.title | Multimodal Imaging Probes for the Diagnostics of Alzheimer’s Disease | por |
dc.type | doctoralThesis | por |
dc.identifier.tid | 101276834 | - |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | doctoralThesis | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.advisor.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.advisor.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.advisor.orcid | 0000-0002-0837-8329 | - |
Appears in Collections: | FCTUC Ciências da Vida - Teses de Doutoramento |
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File | Description | Size | Format | |
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Multimodal Imaging Probes.pdf | Versão provisória | 31.64 MB | Unknown | View/Open |
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